中国医学创新2024，Vol.21Issue(29)：118-122,5.DOI:10.3969/j.issn.1674-4985.2024.29.027
药物涂层球囊在冠状动脉分叉病变中的临床应用研究
Clinical Application Study of Drug-coated Balloon in Coronary Bifurcation Lesion
摘要
Abstract
Objective:To explore and analyze the clinical application effect of drug-coated balloon(DCB)on patients with coronary bifurcation lesion(CBL).Method:A total of 180 patients with CBL admitted to Xinyu People's Hospital from January 2021 to December 2022 were selected and divided into three subgroups according to the disease type,with 60 cases in each group.Subgroup 1 had both main branch and branch stenosis,subgroup 2 had only main branch stenosis,and subgroup 3 had only branch stenosis.The three subgroups were divided into stent group and drug balloon group by random number table method,with 30 cases in each group.The sent group 1 adopted double-stent technique,and the drug balloon group 1 adopted main branch stent and branch DCB technique.The sent group 2 adopted Provisional T technique,and the drug balloon group 2 adopted main branch DCB technique.The sent group 3 adopted single stent precise positioning technique,and the drug balloon group 3 adopted branch DCB technique.All patients were followed up for 12 months after surgery.The minimum lumen diameter(MLD)and degree of stenosis before surgery,after surgery and at the end of follow-up,and late lumen loss(LLL)and restenosis rate at the end of follow-up were compared between the stent group and the drug ball group in all subgroups,and the incidence of major adverse cardiovascular events(MACE)was recorded.Result:The MLD in each group immediately after surgery and at the end of follow-up were increased compared with those before surgery,and the stenosis degree were reduced compared with those before surgery,the differences were statistically significant(P<0.05).There were no statistically significant differences in MLD and stenosis degree among subgroups of drug balloon group and sent group immediately after surgery(P>0.05).At the end of follow-up,the MLD of drug balloon group in each subgroup were higher,and the degree of stenosis were lower than those in sent group,the differences were statistically significant(P<0.05).The LLL and restenosis rate of drug balloon group in each subgroup were lower compared with those in sent group(P<0.05).The total incidence rate of MACE of drug balloon group in each subgroup were lower than those in stent group,the differences were statistically significant(P<0.05).Conclusion:DCB has a good application effect in patients with CBL,which can effectively reduce the risk of postoperative restenosis,avoid revascularization,and reduce the incidence of postoperative MACE.关键词
药物涂层球囊/冠状动脉分叉病变/最小管腔直径/再狭窄率/主要不良心血管事件Key words
Drug-coated balloon/Coronary bifurcation lesion/Minimum lumen diameter/Restenosis rate/Major adverse cardiovascular events引用本文复制引用
夏金兰,胡小武,曾庆宏,李凯..药物涂层球囊在冠状动脉分叉病变中的临床应用研究[J].中国医学创新,2024,21(29):118-122,5.基金项目
新余市科技计划项目(20213090801) （20213090801）
