温素奇 1张国辉 1彭耀宗 1蓝善优 1郭基珍 1张国生1
作者信息
- 1. 广东省人民医院赣州医院(赣州市立医院)普外科 江西 赣州 341000
- 折叠
摘要
Abstract
Objective:To analyze and compare the effects of natural orifice specimen extraction surgery(NOSES)and traditional laparoscopic surgery on gastrointestinal functional recovery and inflammatory response after radical resection of rectal cancer.Method:A total of 96 patients who underwent radical resection of rectal cancer in the Department of General Surgery of Guangdong Provincial People's Hospital Ganzhou Hospital from March 2021 to July 2023 were selected as the study objects.Patients who had undergone traditional laparoscopic surgery were included in the control group,and the NOSES patients were included in the study group,48 patients each.surgery related indexes,postoperative rehabilitation indexes,gastrointestinal function indexes,immune stress indexes and inflammatory factors were compared between the two groups.Result:The anal ventilation time,bowel singing recovery time,gastrointestinal peristalsis time in the study group were earlier than those in control group,and surgery time,hospital stay of the study group were shorter than those of the control group,the intraoperative blood loss was less than that of the control group,and the total incidence of complications was lower than that of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the number of lymph node clearance between the two groups(P>0.05).3 d after surgery,the contents of motilin and gastrin in two groups were lower than those before surgery,and those in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).3 d after surgery,the levels of malondialdehyde(MDA)and superoxide dismutase(SOD)in two groups were significantly higher than those before surgery,but the level of MDA in the study group was lower than that in the control group,and the level of SOD was higher than that in the control group,the differences were statistically significant(P<0.05).3 d after surgery,interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in two groups were lower than those before surgery,and high mobility group protein B1(HMGB1)were higher than those before surgery,and IL-6,TNF-α and HMGB1 in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Compared with traditional laparoscopic surgery,NOSES is more effective in promoting gastrointestinal function recovery,reducing inflammatory response,and reducing postoperative complications in patients with radical rectal cancer surgery.关键词
经自然腔道取标本手术/直肠癌根治术/康复效果/胃肠功能/炎症反应Key words
Natural orifice specimen extraction surgery/Radical resection of rectal cancer/Recovery effect/Gastrointestinal function/Inflammatory response
