中国医学创新2024，Vol.21Issue(30)：1-6,6.DOI:10.3969/j.issn.1674-4985.2024.30.001
参丹散结胶囊辅助艾立布林治疗Her2阴性乳腺癌对免疫功能的影响
Shendan Sanjie Capsules as An Adjunct to Eribulin in the Treatment of Her2 Negative Breast Cancer and Its Effect on Immune Function
摘要
Abstract
Objective:To study the effect of Shendan Sanjie Capsules on immune function in the treatment of Her2 negative breast cancer with Eribulin.Method:A total of 60 cases of Her2 negative advanced breast cancer patients admitted to Ganzhou Cancer Hospital from September 2022 to September 2023 were selected and randomly divided into observation group and control group,with 30 cases each.The control group was treated with Eribulin,and the observation group was treated with this addition of Shendan Sanjie Capsules.The clinical efficacy,tumor marker levels,immune function,biomarker proteins,inflammatory factors,safety,etc.of two groups were evaluated.Result:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of carbohydrate antigen 153(CA153),carcinoembryonic antigen(CEA)and carbohydrate antigen 125(CA125)in observation group were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,CD3+,CD4+and CD4+/CD8+in the observation group were higher than those in the control group,and CD8+was lower than that in the control group,with statistical significance(P<0.05).After treatment,Foxa2 and p27kip1 in the observation group were higher than those in the control group,and proliferating cell nuclear antigen(PCNA)was lower than that in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of inflammatory cytokines tumor necrosis factor-α(TNF-α),soluble interleukin-2 receptor(sIL-2R),interleukin-12(IL-12)and interleukin-6(IL-6)in observation group were lower than those in control group,with statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Shendan Sanjie Capsules combined with Eribulin has better efficacy in the treatment of Her2 negative advanced breast cancer,inhibits the expression of tumor markers,improves immune function and breast cancer related biomarkers,reduces the levels of inflammatory factors,and has good safety.关键词
乳腺癌/艾立布林/参丹散结胶囊/治疗安全性/免疫功能/生活质量Key words
Breast cancer/Eribulin/Shendan Sanjie Capsules/Therapeutic safety/Immune function/Quality of life引用本文复制引用
叶华斌,肖威,刘吉梅,王刚,叶颖,唐金绍..参丹散结胶囊辅助艾立布林治疗Her2阴性乳腺癌对免疫功能的影响[J].中国医学创新,2024,21(30):1-6,6.基金项目
2023年赣州市指导性科技计划项目(2023DXNS4193) （2023DXNS4193）
