中国医学创新2024，Vol.21Issue(30)：6-11,6.DOI:10.3969/j.issn.1674-4985.2024.30.002
舒芬太尼联合艾司氯胺酮自控镇痛对肠道肿瘤根治术后患者免疫调节细胞及炎症因子的影响
Effect of Patient-controlled Analgesia with Sufentanil Combined with Esketamine on Immunomodulatory Cells and Inflammatory Factors in Patients after Radical Resection of Intestinal Tumors
摘要
Abstract
Objective:To analyze the effect of patient-controlled analgesia with Sufentanil combined with Esketamine on immunomodulatory cells and inflammatory factors in patients after radical resection of intestinal tumors.Method:A total of 120 patients with radical resection of intestinal tumors admitted to Department of Gastrointestinal Surgery,Qingyuan Hospital Affiliated to Guangzhou Medical University from January to September 2023 were selected and divided into study group(n=60)and control group(n=60)by random number table method.The postoperative patient-controlled analgesia drug was Sufentanil in the control group and Sufentanil combined with Esketamine in the study group.Immunomodulatory cells,stress and inflammation indexes,blood gas indexes,analgesia scores,heart rate,blood pressure and adverse reactions were compared between the two groups.Result:After medication,positive immunomodulatory cells of both groups were increased,and those in the study group were higher than those in the control group,and negative immunomodulatory cells of both groups were decreased,and those in the study group were lower than those in the control group(P<0.05).After medication,the stress and inflammation indexes of both groups were decreased,and those in the study group were lower than those in the control group(P<0.05).The blood gas indexes of both groups were improved 24 and 48 h after surgery,and the arterial partial pressure of carbon dioxide(PaCO2)48 h after surgery in the study group was lower than that in the control group,and the arterial oxygen saturation(SaO2)and arterial partial pressure of oxygen(PaO2)24,48 h after surgery were higher than those in the control group(P<0.05).The score of numerical rating scale(NRS)24 h after surgery in the study group was lower than that in the control group(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group(5%vs 18%),the difference was statistically significant(P<0.05).Conclusion:The use of patient-controlled analgesia with Sufentanil combined with Esketamine in patients with radical resection of intestinal tumors is more conducive to restoring the balance of immunomodulatory cells,improving stress and inflammation indexes,and has high safety.关键词
艾司氯胺酮/舒芬太尼/肠道肿瘤根治术/免疫调节细胞/炎症因子Key words
Esketamine/Sufentanil/Radical resection of intestinal tumors/Immunomodulatory cells/Inflammatory factors引用本文复制引用
龚建平,刘玉妍,黄义洲,梁秀生,刘小丹,李恒..舒芬太尼联合艾司氯胺酮自控镇痛对肠道肿瘤根治术后患者免疫调节细胞及炎症因子的影响[J].中国医学创新,2024,21(30):6-11,6.基金项目
广东省医学科学技术研究基金项目(B2023113) （B2023113）
