中国医学创新2024，Vol.21Issue(30)：34-38,5.DOI:10.3969/j.issn.1674-4985.2024.30.008
不同剂量艾司氯胺酮复合丙泊酚应用于腹腔镜下结直肠癌根治术老年患者效果及对苏醒质量的影响
Effect of Different Doses of Esketamine Combined with Propofol on Elderly Patients Undergoing Laparoscopic Radical Resection of Colorectal Cancer and Its Influence on the Quality of Awakening
摘要
Abstract
Objective:To compare the anesthetic effect of different doses of Esketamine combined with Propofol on elderly patients undergoing laparoscopic radical resection of colorectal cancer and its influence on the quality of awakening,and to explore the optimal dosage of Esketamine.Method:A total of 120 elderly patients who underwent selective laparoscopic radical resection of colorectal cancer under general anesthesia in First Affiliated Hospital of Gannan Medical University from February 2023 to April 2024 were selected and randomly divided into four groups,with 30 cases in each group.The low-dose group was given Esketamine 0.1 mg/kg,the medium-dose group was given Esketamine 0.3 mg/kg,the high-dose group was given Esketamine 0.5 mg/kg,and the control group was given 10 mL normal saline.The mean arterial pressure(MAP)and heart rate(HR)of the four groups were recorded at different time points,and operative time,blood loss,infusion volume,urine volume,maintenance anesthesia dosage,postoperative recovery related indexes and complications of the four groups were recorded.Result:There were no significant differences in MAP and HR among the four groups at different time points(P>0.05).There were no significant differences in operative time,blood loss,infusion volume and urine volume among the four groups(P>0.05).Compared with control group,the dosage of Propofol and Remifentanil in high-dose group were lower,the differences were statistically significant(P<0.05).Compared with the control group,the postoperative eye opening time and extubation time in the medium-dose group and high-dose group were shorter,the differences were statistically significant(P<0.05).There was no significant difference in postanesthesia care unit(PACU)residence time among the four groups(P>0.05).Compared with the control group and the low-dose group,the visual analogue scale(VAS)score after extubation in the high-dose group was lower,the differences were statistically significant(P<0.05).There were no significant differences in the incidences of adverse reactions among the four groups(P>0.05).Conclusion:The application of 0.3 mg/kg Esketamine in elderly patients undergoing laparoscopic radical resection of colorectal cancer has a faster postoperative recovery,but the dosage of 0.5 mg/kg has a better analgesic effect and can reduce the dosage of Propofol and Remifentanil during operation.关键词
艾司氯胺酮/全身麻醉/结直肠癌/苏醒质量Key words
Esketamine/General anesthesia/Colorectal cancer/Awakening quality引用本文复制引用
刘金龙,邓子豪,卓明,钟茂林..不同剂量艾司氯胺酮复合丙泊酚应用于腹腔镜下结直肠癌根治术老年患者效果及对苏醒质量的影响[J].中国医学创新,2024,21(30):34-38,5.基金项目
江西省卫生健康委科技计划项目(202310742) （202310742）
