中国医学创新2024，Vol.21Issue(30)：55-59,5.DOI:10.3969/j.issn.1674-4985.2024.30.013
加巴喷丁治疗维持性血液透析患者皮肤瘙痒的临床研究
Clinical Study on Gabapentin in the Treatment of Skin Pruritus in Maintenance Hemodialysis Patients
摘要
Abstract
Objective:To study the clinical effect of Gabapentin(GBP)in the treatment of skin pruritus in maintenance hemodialysis(MHD)patients.Method:Using random number table method,80 MHD patients with skin pruritus who were admitted to the First People's Hospital of Fuzhou from July 2022 to September 2023 were divided into control group(40 cases)and observation group(40 cases).The control group was treated with Urea Cream combined with high-flux hemodialysis(HFHD).On this basis,the observation group was treated with GBP.Comparison between groups was made on clinical efficacy,renal function indicators,inflammatory factors,clearance of mediummolecular and macromolecular toxins,degree of skin pruritus and adverse reactions.Result:After treatment,the total effective rate of observation group(95.00%)was significantly higher than that of control group(80.00%),the difference was statistically significant(P<0.05).After treatment,pruritus scores of both groups decreased,and those of observation group were lower than those of control group,the differences were statistically significant(P<0.05).After treatment,the levels of parathyroid hormone(PTH),and serum β2-microglobulin(β2-MG)in both groups decreased,the differences were statistically significant(P<0.05),however,there were no statistically significant differences in the levels of PTH and β2-MG between two groups(P>0.05).After treatment,the levels of interleukin-6(IL-6),interleukin-1β(IL-1β)and hypersensitivity C reactive protein(hs-CRP)in both groups decreased(P<0.05),the differences were statistically significant(P<0.05),however,there were no statistically significant differences in the levels of IL-6,IL-1β and hs-CRP between two groups(P>0.05).After treatment,the levels of serum creatinine(Scr),blood urea nitrogen(BUN)and phosphorus(P)in both groups decreased,while the levels of calcium(Ca)increased,the differences were statistically significant(P<0.05),however,there were no statistically significant differences in Scr,BUN,Ca and P between two groups(P>0.05).No adverse reaction was observed in either group.Conclusion:Additional use of GBP on the basis of HFHD and Urea Cream can effectively relieve skin pruritus in MHD patients with skin pruritus.Besides,the application of GBP has no significant influence on HFHD in terms of toxin clearance,renal function and inflammatory factors,indicating good safety.关键词
维持性血液透析/皮肤瘙痒/高通量血液透析/加巴喷丁/尿素霜Key words
Maintenance hemodialysis/Skin pruritus/High-flux hemodialysis/Gabapentin/Urea Cream引用本文复制引用
黄娟,张素云,黄洁,赵子强..加巴喷丁治疗维持性血液透析患者皮肤瘙痒的临床研究[J].中国医学创新,2024,21(30):55-59,5.基金项目
抚州市社会发展指导性科技计划项目(抚科社字(2023)7号第24项) （抚科社字(2023）
