摘要
Abstract
Objective:To investigate the efficacy of laparoscopic radical resection for colorectal cancer(LRRC)with two port technique in colorectal cancer.Method:A retrospective analysis was conducted on the clinical data of 84 patients with colorectal cancer admitted to Jiangxi Province Hospital of Integrated Chinese and Western Medicine from January 2021 to January 2024.According to different surgical methods,42 cases who received conventional porous LRRC were set as the control group,and 42 cases who received two port LRRC were set as the observation group.The surgical conditions,serum stress indicators,T lymphocyte subsets,tumor markers,and complications between two groups were compared.Result:The first time of getting out of bed,the first time of exhalation and the postoperative hospitalization time in the observation group were(26.88±2.42)hours,(40.25±4.35)hours and(8.41±1.28)days,respectively,which were shorter than(34.68±3.57)hours,(51.74±5.89)hours and(11.05±1.34)days in the control group,the differences were statistically significant(P<0.05);the postoperative levels of cortisol,adrenocorticotropic hormone and norepinephrine in the observation group were(759.65±55.82)nmol/L,(19.55±1.54)pmol/L,and(87.14±5.59)μg/L,which were lower than(824.28±66.07)nmol/L,(22.06±2.42)pmol/L,and(99.52±6.83)μg/L in the control group,with statistical significance(P<0.05);the postoperative CD4+and CD4+/CD8+in the observation group were(35.41±3.25)%and(1.19±0.21),which were higher than(31.84±3.19)%and(1.00±0.19)in the control group,respectively,CD8+was(29.86±2.57)%,which was lower than(31.89±2.87)%in the control group,with statistical significance(P<0.05);there were no statistically significant differences in the levels of tumor markers after surgery and complication rate between the two groups(P>0.05).Conclusion:Two port LRRC treatment is more effective in treating colorectal cancer,reducing surgical stress response,shortening the postoperative activity of getting out of bed,exhaust time,etc.,alleviating immune suppression caused by trauma,and with acceptable safety.关键词
结直肠癌/两孔法腹腔镜结直肠癌根治术/应激指标/T淋巴细胞亚群Key words
Colorectal cancer/Two port laparoscopic radical resection for colorectal cancer/Stress indicators/T lymphocyte subpopulation
