摘要
Abstract
Objective:To analyze the relationship between glutamic acid,C reactive protein(CRP)and S-100β protein levels and prognosis of cerebral hemorrhage patients.Method:A total of 80 cerebral hemorrhage patients admitted to the Fourth Affiliated Hospital of Nanchang University from January 2021 to December 2023 were selected.Blood samples were collected after admission to determine serum glutamate,CRP and S-100β protein levels.After 90 days of follow-up,Glasgow prognosis scale(GPS)was used to evaluate the prognosis,and GPS score was used to divide the two groups into poor prognosis group(1-3 points)and good prognosis group(4-5 points).Glutamic acid,CRP and S-100β protein levels were compared between the two groups,and the correlation between glutamic acid,CRP and S-100β protein levels and prognosis was analyzed.The value of these biomarkers for prognostic prediction were analyzed using receiver operating characteristic(ROC)curves.Result:Among 80 patients with cerebral hemorrhage,the incidence of poor prognosis was 43.75%(35/80).The levels of glutamic acid,CRP and S-100β protein in the poor prognosis group were higher than those in the good prognosis group(P<0.05).Two-column correlation coefficient analysis showed that glutamic acid,CRP and S-100β were positively correlated with prognosis(r=0.709,0.764,0.654,P<0.05).Pearson correlation coefficient analysis showed that glutamic acid and CRP were positively correlated with S-100β protein(r=0.361,0.431,P<0.001).ROC curve showed that the AUC of glutamic acid,CRP and S-100β protein in predicting the prognosis of patients were 0.912,0.945 and 0.881,respectively,which had certain predictive value.Conclusion:Glutamic acid,CRP and S-100β protein levels are positively correlated with the prognosis of patients with cerebral hemorrhage,and have certain predictive value,which can be used as one of the important reference indicators in evaluating the prognosis of patients with cerebral hemorrhage.关键词
脑出血/谷氨酸/C反应蛋白/S-100β蛋白Key words
Cerebral hemorrhage/Glutamic acid/C reactive protein/S-100 β protein
