中国医学创新2024，Vol.21Issue(30)：114-118,5.DOI:10.3969/j.issn.1674-4985.2024.30.026
CRP、CK-MB、NT-proBNP、cTnI与慢性心力衰竭患者心功能及主要不良心血管事件的关系
Relationship between CRP,CK-MB,NT proBNP,cTnI and Cardiac Function and Occurrence of Major Adverse Cardiovascular Events in Patients with Chronic Heart Failure
摘要
Abstract
Objective:To explore the relationship between C reactive protein(CRP),creatine kinase isoenzyme(CK-MB),N-terminal brain natriuretic peptide precursor(NT-proBNP),cardiac troponin I(cTnI)and cardiac function and major adverse cardiovascular events(MACE)in patients with chronic heart failure(CHF).Method:A total of 100 patients with CHF who were hospitalized in the Internal Medicine Department of Shaozhou People's Hospital of Shaoguan City from January 2021 to May 2023 were selected as the observation group,and 50 healthy volunteers who underwent physical examination with the hospital during the same period were selected as the control group.The levels of CRP,CK-MB,NT-proBNP and cTnI were compared between the two groups,and the relationship between the levels of CRP,CK-MB,NT-proBNP and cTnI and cardiac function in the observation group was analyzed.Receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of CRP,CK-MB,NT-proBNP and cTnI levels for MACE in CHF patients.Result:The levels of CRP,CK-MB,NT-proBNP and cTnI in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The levels of serum CRP,CK-MB,NT-proBNP and cTnI in New York heart association(NYHA)heart function grade Ⅲ and Ⅳ patients were higher than those in grade Ⅱ patients,and those in grade Ⅳ were higher than those in grade Ⅲ,the differences were statistically significant(P<0.05).NYHA heart function grade was positively correlated with serum CRP,CK-MB,NT-proBNP and cTnI levels in CHF patients(rs=0.780,0.655,0.730,0.809,P<0.05).The levels of CRP,CK-MB,NT-proBNP and cTnI in MACE patients were higher than those in non-MACE patients,the differences were statistically significant(P<0.05).The area under the curve of MACE in CHF patients predicted by the combination of serum CRP,NT-proBNP,CK-MB and cTnI was 0.909,which was higher than 0.875,0.758,0.826 and 0.812 predicted by CRP,CK-MB,NT-proBNP and cTnI alone(P<0.05).Conclusion:The levels of serum CRP,CK-MB,NT-proBNP and cTnI are abnormally elevated in CHF patients,and are positively correlated with the cardiac function grade of patients.Detection of the above indicators can be used to predict the occurrence of MACE in patients.关键词
慢性心力衰竭/C反应蛋白/肌酸激酶同工酶/N末端脑利钠肽前体/心肌肌钙蛋白Ⅰ/心功能/心血管不良事件Key words
Chronic heart failure/C reactive protein/Creatine kinase isoenzyme/N-terminal brain natriuretic peptide precursor/Cardiac troponin I/Heart function/Cardiovascular adverse events引用本文复制引用
钟达香,肖祖华,李伟东..CRP、CK-MB、NT-proBNP、cTnI与慢性心力衰竭患者心功能及主要不良心血管事件的关系[J].中国医学创新,2024,21(30):114-118,5.基金项目
广东省韶关市卫生健康科研项目(Y24158) （Y24158）
