摘要
Abstract
Objective:To investigate the effects of Terlipressin combined with Norepinephrine on D-lactic acid and myocardial injury indexes in patients with septic shock in intensive care unit(ICU).Method:A total of 116 patients with septic shock admitted to the First Affiliated Hospital of Soochow University from January 2019 to December 2023 were retrospectively selected and divided into two groups according to different treatment methods,with 58 cases in each group.Both groups were given routine treatment,the control group was given Norepinephrine treatment,and the observation group was combined with Terlipressin treatment on the basis of the control group.D-lactic acid,myocardial injury indexes,renal function and adverse reactions were compared between the two groups.Result:There were no significant differences in D-lactic acid,myocardial injury indexes and renal function indexes between the two groups before treatment(P>0.05).After 36 h of treatment,D-lactic acid,creatine kinase MB(CK-MB),cardiac troponin I(cTnI),N-terminal pro-brain natriuretic peptide(NT-proBNP),cystatin C(CysC),serum creatinine(Scr)and blood urea nitrogen(BUN)in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Terlipressin combined with Norepinephrine in the treatment of patients with septic shock in ICU can effectively reduce D-lactic acid level,improve renal function,alleviate myocardial injury,and is safe and reliable.关键词
重症监护室/脓毒性休克/特利加压素/去甲肾上腺素/D-乳酸/心肌损伤/肾功能Key words
Intensive care unit/Septic shock/Terlipressin/Norepinephrine/D-lactic acid/Myocardial injury/Renal function
