摘要
Abstract
Objective:To explore the therapeutic efficacy and safety of different antibiotics in the treatment of neonatal pneumonia.Method:A total of 105 children diagnosed with neonatal pneumonia from March 2021 to March 2022 in Department of Neonatology,Gao'an Maternal and Child Health Hospital were selected as the study objects,and divided into three groups according to random number table method,with 35 cases in each group.Group A was treated with Cefotaxime,and group B was treated with Penicillin.Group C was treated with the combination of two drugs.The total effective rate,the incidence of adverse reactions during treatment and the number of intestinal microbes on the 3rd and 7th day of antibiotic treatment were compared among the three groups.Result:There was no significant difference in the total effective rate between group A and group B(P>0.05).The total effective rate of group C was higher than those of group A and group B(P<0.05).There was no significant difference in the incidence of adverse reactions between group A and group B(P>0.05).The incidence of adverse reactions in group C was lower than those in group A and group B(P<0.05).On the 3rd day of antibiotic treatment,the numbers of Enterobacteriaceae,Pseudomonas,Bifidobacterium,Enterococcus,and Lactobacillus in the group C were lower than those in group A and group B(P<0.05),and the number of Enterobacter was higher than that in group B but lower than that in group A(P<0.05).On the 7th day of antibiotic treatment,the numbers of the above 6 microbial species in group C were lower than those in group A and group B(P<0.05).Conclusion:Different antibiotics have varying effects on the treatment of neonatal pneumonia,and combined use of antibiotics has a greater impact on the intestinal microbiota than the use of a single antibiotic.The efficacy,safety,and impact on microbial community balance of antibiotics should be comprehensively considered in clinical applications.关键词
新生儿肺炎/青霉素/头孢噻肟Key words
Neonatal pneumonia/Penicillin/Cefotaxime
