中国真菌学杂志2024，Vol.19Issue(5)：433-439,7.
106例HIV合并马尔尼菲篮状菌感染特征及预后不良相关因素分析
Analysis of characteristics and poor prognosis factors in 106 cases of HIV and Talaromyces mameffei coin-fections
摘要
Abstract
Objective To analyze the characteristics of HIV positive cases with Talaromyces mameffei infection and the associated factors of poor prognosis.Methods A retrospective analysis was performed to analyze the general characteristic,clinical comorbidities and prognostic correlation of 106 cases of HIV positive cases complicated with Talaromyces mameffei infection from February 2020 to December 2023 in The People's Hospital of Hechi.Results There were statistical differences in the progression of HIV-TSM infection between Zhuang and other ethnic groups(P＜0.05).The comorbidities of sepsis,metabolic acidosis and thrombocytopenia showed significantly different composition ratio between the improved group and the deteriorating group(P＜0.001).In univariate Cox analysis,metabolic acidosis,thrombocytopenia and sepsis were correlate-d with severe symptoms.In multivariate Cox analysis,thrombocytopenia was as an independent risk factor for severe disease(HR=2.955,95％CI=1.304～6.699;P=0.009),metabolic acidosis was an independent risk factor for severe disease(HR=6.219,95％CI=2.740～14.116;P＜0.001).Kaplan-Meier analysis suggested that thrombocytopenia was associated with HIV-TSM prognosis(Log-Rand,x2=11.511,P＜0.001),and metabolic acidosis was associated with HIV-TSM prog-nosis(Log-Rand,=44.847,P＜0.001).The area under ROC curve predicted by thrombocytopenia combined with meta-bolic acidosis was 0.794(P＜0.001,95％CI:0.690～0.892).Conclusion Compared with other ethnic groups,Zhuang pop-ulation in northwestern Guangxi has a significant difference in the poor prognosis of HIV-TSM infection,thrombocytopenia and metabolic acidosis are independent risk factors for the poor prognosis of HIV-TSM infection.关键词
人类免疫缺陷病毒/马尔尼菲篮状菌/预后/壮族/代谢性酸中毒/血小板减少Key words
human immunodeficiency virus/Talaromyces mameffei/prognosis/the Zhuang nationality/metabolic acido-sis/thrombopenia分类
医药卫生引用本文复制引用
韦叙,梁慧娜,夏益贵,陈高,蓝晨,韦例村,薛莲,韦帅,廖显秀,韦浩飞,梁丽花,黄强..106例HIV合并马尔尼菲篮状菌感染特征及预后不良相关因素分析[J].中国真菌学杂志,2024,19(5):433-439,7.基金项目
广西真菌研究与真菌病防治重点实验室开放课题(GXHCFM202109) （GXHCFM202109）
广西亚热带真菌与真菌病研究重点实验室开放课题(YYZS2020006) （YYZS2020006）
