中国真菌学杂志2024，Vol.19Issue(5)：480-486,7.
多指标单独或联合检测在艾滋病合并马尔尼菲篮状菌感染的诊断价值
The diagnostic value of multiple indicators alone or unite test in AIDS patients complicated with Talaromy-ces marnef fei infection
摘要
Abstract
Objective To explore the diagnostic value of multiple indicators alone or unite test in AIDS patients complicated with Talaromyces marneffei infection.Method Retrospective analysis of the clinical data of AIDS patients hospitalized in our hospital from October 2018 to December 2021,The data of 789 patients were obtained by the standard screening.Ac-cording to the results of Talaromyces marneffei isolation,culture,identification and clinical diagnosis,157 cases of con-firmed AIDS complicated with Talaromyces marneffei infection were defined as the TM group;632 AIDS patients without Talaromyces marneffei infection were defined as the non-TM group.Mann-Whitney U test was used to compare the differ-ences in PCT,ADA,LDH,GM,G and T lymphocyte counts of CD3+,CD8+and CD4+between the two groups.ROC curve was used to analyze the diagnostic value of PCT,ADA,LDH,GM and G in AIDS patients complicated with TM infec-tion whose CD4+T lymphocyte counts ≤50 cells/μL.Analyzing the value of combined GM,ADA,and G tests in AIDS pa-tients complicated with TM infection whose CD4+T lymphocyte counts ≤50 cells/μL.Results The levels of PCT,ADA,LDH,GM and G in the TM group were significantly higher than those in the non-TM group,and the difference was statisti-cally significant(P＜0.0001),The CD34,CD84,and CD44 T lymphocyte counts in the TM group were significantly lower than those in the non-TM group,and the difference was statistically significant(P＜0.0001).After ROC curve analysis,it was concluded that GM,ADA and G were of high diagnostic value in AIDS patients complicated with TM infection whose CD4+T lymphocyte counts ≤50 cells/μL.ADA,GM,and G in tandem had the highest specificity(99.53％)and positive predictive value(98.15％)among all protocols for unite testing.ADA and G tandem had the highest diagnostic accuracy(77.26％).The sensitivity(96.03％)and negative predictive value(94.17％)of ADA,GM and G in parallel were the high-est.Conclusion AIDS complicated with TM infection mainly occurred in patients whose CD4+T lymphocyte counts ≤50 cells/μL.High diagnostic value of GM,ADA,and G tests in AIDS patients complicated with TM infection whose CD4+T lymphocyte counts ≤50 cells/μL.The combination of GM,ADA and G has the best diagnostic efficacy among all protocols for unite testing,which can effectively improve the rate of disease detection.关键词
艾滋病/马尔尼菲篮状菌/CD4+T淋巴细胞计数/ROC曲线分析/联合检测Key words
AIDS/Talaromyces marnef fei/CD4+T lymphocyte count/ROC curve analysis/unite test分类
医药卫生引用本文复制引用
周游,何希,黄丽花,潘艳娜,黄丽玲,廖家吉,蓝吉慧,覃善芳..多指标单独或联合检测在艾滋病合并马尔尼菲篮状菌感染的诊断价值[J].中国真菌学杂志,2024,19(5):480-486,7.基金项目
广西重点研发计划(桂科 AB23026050) （桂科 AB23026050）
广西医疗卫生适宜技术开发与推广应用项目(S2022042) （S2022042）
