中山大学学报（自然科学版）（中英文）2024，Vol.63Issue(6)：254-264,11.DOI:10.13471/j.cnki.acta.snus.ZR20240112
四维细胞核体调控基因表达的数学理论
Mathematical theory of four-dimensional nucleome regulating gene expression
摘要
Abstract
The multiscale three-dimensional genome structure drives gene expression and cell-fate deci-sion.Although significant progress has been made in the study of one-dimensional linear genomes,it is still unclear how the dynamic structure of three-dimensional spatial genomes affects spatiotemporal gene expression changes functionally.In recent years,the development of sequencing and imaging technologies has led to a series of advances in the study of four-dimensional nucleome genomics.In this review,we discuss the multiscale nature of the three-dimensional genome structure,its complex regulation of gene expression,and its spatiotemporal dynamics.Subsequently,we theoretically model this complex chromatin structure dynamics,epigenetic modification dynamics,and gene expression dynamics,and propose a predictive multiscale coupled modeling framework.Finally,we discuss fu-ture research directions on four-dimensional nucleome dynamics.关键词
三维基因组/基因表达/染色质构象/表观修饰/基因调控Key words
three-dimensional genome/gene expression/chromatin conformation/epigenetic modifi-cation/gene regulation分类
数理科学引用本文复制引用
王子豪,张圳泉,张家军..四维细胞核体调控基因表达的数学理论[J].中山大学学报（自然科学版）（中英文）,2024,63(6):254-264,11.基金项目
国家自然科学基金(12171494) （12171494）
