安徽医科大学学报2024，Vol.59Issue(10)：1856-1862,7.DOI:10.19405/j.cnki.issn1000-1492.2024.10.023
对于干燥综合征与原发性胆汁性胆管炎以及肝功能异常关系的新见解:一项孟德尔随机化研究
New insights into the relationship between Sjogren's syndrome and primary biliary cholangitis and abnormal liver function:a Mendelian randomization study
摘要
Abstract
Objective To analyze the causal relationship between Sjogren's syndrome(SS)and primary biliary cholangitis(PBC)and abnormal liver function by two-sample Mendelian randomization.Methods From the ge-nome-wide association study,single nucleotide polymorphisms of SS,PBC,alkaline phosphatase,alanine amin-otransferase,aspartate aminotransferase,γ-glutamyltransferase,direct bilirubin and total bilirubin levels were extrac-ted as instrumental variables.Inverse-variance weighted(IVW)analysis was used as the main analysis,supplemen-ted by weighted median,MR-Egger,weighted mode,and simple mode.And a series of sensitivity analyses were car-ried out to verify the robustness of the results.Results The IVW analysis results of PBC on SS were as follows:P=8.57E-11,OR=1.185 9,95％CI=1.126 4-1.248 5;IVW analysis of PBC on SS(P＞0.05).IVW analysis results of SS on alkaline phosphatase were as follows:P=0.041 5,Beta=-0.007 2,95％CI=-0.014 0--0.000 3;IVW analysis results of SS on alanine aminotransferase,aspartate aminotransferase,γ-glutamyltransferase,direct bilirubin,total bilirubin levels showed no statistically significant difference.Conclusion PBC can significantly increase the risk of SS,but SS cannot be proved to have a causal effect on the occurrence of PBC.SS has a potential effect on re-ducing alkaline phosphatase levels,but it is not proved that SS has causal relationship with alanine aminotransferase,aspartate aminotransferase,γ-glutamyltransferase,direct bilirubin,total bilirubin levels.关键词
孟德尔随机化/因果关系/原发性胆汁性胆管炎/干燥综合征/肝功能异常Key words
Mendelian randomization/causal relationship/primary biliary cholangitis/Sjogren's syndrome/abnor-mal liver function分类
医药卫生引用本文复制引用
周莉涵,徐俊,郭晟,李逸雪,徐子皓,程良斌..对于干燥综合征与原发性胆汁性胆管炎以及肝功能异常关系的新见解:一项孟德尔随机化研究[J].安徽医科大学学报,2024,59(10):1856-1862,7.基金项目
国家自然科学基金项目(编号:82274367) （编号:82274367）
湖北省自然科学基金项目(编号:2024AFD328) （编号:2024AFD328）
全国名老中医药专家传承工作室建设项目(编号:国中医药人教函[2022]75号) National Natural Science Foundation of China(No.82274367) （编号:国中医药人教函[2022]75号）
Natural Science Foundation of Hubei Province(No.2024AFD328) （No.2024AFD328）
National Inheritance Workshop for Famous Traditional Chinese Medicine Experts(No.75[2022]of The National Administration of Traditional Chinese Medicine Education) （No.75[2022]of The National Administration of Traditional Chinese Medicine Education）
