安徽医科大学学报2024，Vol.59Issue(10)：1871-1874,1880,5.DOI:10.19405/j.cnki.issn1000-1492.2024.10.025
肌少症与绝经后2型糖尿病患者骨质疏松的相关性研究
Correlation of sarcopenia and osteoporosis in postmenopausal elderly patients with type 2 diabetes
摘要
Abstract
Objective To investigate the correlation between the appendicular skeletal mass index(ASMI)and os-teoporosis(OP)in postmenopausal patients with type 2 diabetes(T2DM).Methods 164 hospitalized postmeno-pausal elderly T2DM patients were selected and their bone density(BMD)and appendicular skeletal mass were measured using dual energy X-ray absorption method(DXA).ASMI=appendicular skeletal mass/height2(kg/m2),and they were divided into OP group and non OP group based on T value.The general clinical data,blood biochemical indicators,and ASMI between the two groups were compared,and Logistic regression analysis,ROC curve were further used to analyze the correlation and diagnostic power.Results Compared with non OP group,OP group had a higher incidence of sarcopenia(SAC)(P＜0.05);the differences in age,ASMI,body mass index(BMI),and estradiol(E2)had significant differences between the two groups(P＜0.05);Logistic regression analysis showed that the reduction of ASMI[OR=0.133,95％CI(0.029-0.611)],BMI[OR=0.785,95％CI(0.625-0.985)],and E2[OR=0.967,95％CI(0.942-0.993)]were protective factors for OP;receiver operating curve(ROC)suggested that the AUC of ASMI for OP prediction was 0.752[95％CI(0.632-0.872),P＜0.001]with sensitivity 87.5％,specificity 47.8％,and the best diagnostic value was 5.52 kg/m2.Conclusion The reduction of ASMI,BMI,and E2 is positively correlated with the occurrence of osteoporosis.ASMI is an important protective factor for osteoporosis.Early OP screening and risk factor assessment should be conducted for elderly postmenopausal T2DM patients,and early intervention measures should be taken to reduce the risk of falls and fractures.关键词
2型糖尿病/骨质疏松/骨密度/肌少症/四肢骨骼肌质量指数Key words
type 2 diabetes/osteoporosis/bone mineral density/sarcopenia/appendicular skeletal mass index分类
医药卫生引用本文复制引用
张萍,杜益君,王跃,王艳秋,徐小群,潘天荣..肌少症与绝经后2型糖尿病患者骨质疏松的相关性研究[J].安徽医科大学学报,2024,59(10):1871-1874,1880,5.基金项目
安徽省卫生健康科研项目(编号:AHWJ2023A10010) （编号:AHWJ2023A10010）
安徽医科大学校科研基金项目(编号:2022xkj177) Health Research Project of Anhui Province(No.AHWJ2023A10010) （编号:2022xkj177）
Scientific Research Pro-ject of Anhui Medical University(No.2022xkj177) （No.2022xkj177）
