波谱学杂志2024，Vol.41Issue(4)：363-372,10.DOI:10.11938/cjmr20243106
超极化129Xe MR用于COPD急性加重的肺功能研究
Assessment of Pulmonary Function Changes of AECOPD with Hyperpolarized 129Xe MR
摘要
Abstract
The acute exacerbation of chronic obstructive pulmonary disease(AECOPD)constitutes a significant adverse event in the trajectory of COPD.In this study,we utilized hyperpolarized 129Xe magnetic resonance(MR)to explore the alterations in alveolar microstructure and pulmonary gas exchange function in an AECOPD disease model.Our findings revealed that,in comparison to the emphysema group,the microstructure remained relatively unchanged in the acute exacerbation group,while gas exchange function exhibited a decrease.Notably,these observed changes correlated well with histological findings and pulmonary function assessments,indicating the feasibility and sensitivity of hyperpolarized 129Xe MR in detecting AECOPD.关键词
超极化129Xe MR/扩散加权成像/化学位移饱和恢复/COPD/肺气肿/急性加重Key words
hyperpolarized 129Xe MR/DWI/CSSR/COPD/emphysema/acute exacerbation分类
数理科学引用本文复制引用
李连杰,范丽,萧毅,刘士远,周欣,郑瑜,谢树光,张鸣,李红闯,刘小玲,赵修超,韩叶清,李海东..超极化129Xe MR用于COPD急性加重的肺功能研究[J].波谱学杂志,2024,41(4):363-372,10.基金项目
国家自然科学基金项目(81930049,82127802,21921004,82372150,82202119)、国家重点研发计划(2018YFA0704000,2022-YFC2410000)、湖北省科技重大专项(2021ACA013,2023BAA021)、中国科学院重点项目(ZDBS-LY-JSC004,XDB0540000)和中国科学院青年促进会专项(2020330,2021330). （81930049,82127802,21921004,82372150,82202119）
