波谱学杂志2024，Vol.41Issue(4)：373-381,9.DOI:10.11938/cjmr20243105
基于核自旋单重态的活体谷胱甘肽分子MRS信号选择
In Vivo Glutathione Molecular MRS Signal Selection Based on Nuclear Spin Singlet States
摘要
Abstract
Glutathione(GSH),a tripeptide derived from glutamic acid,cysteine,and glycine,as a vital source of reducing power in the body,is crucial for maintaining redox balance and combating free radicals.Its role in tumor therapy is also significant.Monitoring GSH levels in vivo using magnetic resonance spectroscopy(MRS)is essential for understanding its biological functions.However,due to complex biological environments,overlapping problem of MRS signals is often serious,which makes selective detection and accurate quantification challenging.This paper introduces a method to selectively detect GSH in vivo by using nuclear spin singlet states.Compared to other methods in literatures,our method offers high efficiency and strong selectivity.关键词
磁共振波谱/谷胱甘肽/分子靶向信号检测/核自旋单重态/优化控制脉冲Key words
MRS/glutathione/molecular targeted signal selection/nuclear spin singlet state/optimal control pulse分类
数理科学引用本文复制引用
朱向炜,杨雪,魏达秀,姚叶锋..基于核自旋单重态的活体谷胱甘肽分子MRS信号选择[J].波谱学杂志,2024,41(4):373-381,9.基金项目
上海市科委"科技创新行动计划"(22142200800). （22142200800）
