海南医学院学报2024，Vol.30Issue(22)：1751-1760,10.DOI:10.13210/j.cnki.jhmu.20240904.003
白脂素与心血管代谢性疾病及其运动调节
Asprosin and cardiovascular metabolic diseases,regulation of exercise
摘要
Abstract
Cardiometabolic disease(CMD)is a general term for metabolic diseases and cardiovascular diseases.Asprosin(ASP),as a new adipokine,is involved in the occurrence of CMD such as obesity,type 2 diabetes mellitus,non-alcoholic fatty liver disease,coronary artery disease due to its high circulating levels and biological functions such as appetite promotion,glucose elevation,and pro-inflammatory effects.Exercise can reduce serum ASP levels in CMD patients and may further reduce inflamma-tory response and lipid deposition through TLR4/NF-κB pathway,regulateing blood sugar through AMPK/TGF-β mediated by PKA,and improving cardiovascular function through TGF-β-Smad2/3 pathways.This article provides a review on the role and possible mechanisms of ASP in CMD,as well as the regulation of exercise.关键词
白脂素/心血管代谢性疾病/2型糖尿病/肥胖Key words
Asprosin/Cardiometabolic disease/Type 2 diabetes/Obesity分类
医药卫生引用本文复制引用
邵林林,熊晓玲,钱帅伟,李春艳..白脂素与心血管代谢性疾病及其运动调节[J].海南医学院学报,2024,30(22):1751-1760,10.基金项目
General Project of Humanities and Social Sciences Research,Ministry of Education(22YJCZH138) （22YJCZH138）
Wuhan Institute of Physical Education Young and Middle-Aged Research Team(21KT11) （21KT11）
Humanities and Social Sciences Research Project of Ministry of Education(21YJA890014) 教育部人文社会科学研究一般项目(22YJCZH138) （21YJA890014）
武汉体育学院中青年科研团队(21KT11) （21KT11）
教育部人文社会科学研究项目(21YJA890014) （21YJA890014）
