血清IL-6 IL-17及IL-35水平与儿童急性淋巴细胞白血病病情及化疗疗效的研究OACSTPCD

Objective:To analyze the changes of serum interleukin-6(IL-6),interleukin-17(IL-17)and interleukin-35(IL-35)levels in children with acute lymphoblastic leukemia(ALL)with different disease conditions and chemotherapy efficacy.Methods:A total of 95 children with ALL admitted to the hos-pital from October 2018 to October 2023 were divided into initial stage group(n=45)and advanced stage group(n=50)according to the severity of admission examination.By means of efficacy after 1 cycle of chem-otherapy,they were classified into remission group(n=70)and non-remission group(n=25).Serum IL-6,IL-17 and IL-35 levels were measured among the study subjects.Binary Logistic regression analysis was used to construct an evaluation model with serum IL-6,IL-17 and IL-35 levels as variables.Receiver operating characteristic curve(ROC)was applied to analyze the evaluated value of serum IL-6,IL-17 and IL-35 on disease condition of children.Results:The levels of serum IL-6,IL-17 and IL-35 of advanced stage group were higher than initial stage group(P<0.05).Serum IL-6,IL-17 and IL-35 of non-remission group were higher than remission group(P<0.05).Logistic regression analysis indicated that serum IL-6,IL-17 and IL-35 were independent risk factors for disease progression of children with ALL,and the evaluation model was logit(P)=-7.052+0.206×IL-6+0.238×IL-17+0.406×IL-35.ROC analysis suggested the AUC of serum IL-6,IL-17 and IL-35 levels combined to evaluate the severity of childhood acute lymphoblastic leukemia was 0.918,the sensitivity was 80.00%,and the specificity was 95.56%,which was better than that of each index alone(P<0.05).Conclusion:Serum levels of IL-6,IL-17 and IL-35 are significantly different a-mong ALL children with different disease conditions and chemotherapy efficacy.Early detection of serum IL-6,IL-17 and IL-35 can provide certain reference value for the evaluation of leukemia.