河北医学2024，Vol.30Issue(11)：1834-1839,6.DOI:10.3969/j.issn.1006-6233.2024.11.014
中性粒细胞联合凝血参数预测颅脑外伤术后下肢深静脉血栓的价值分析
Value of Neutrophil Combined with Coagulation Parameters on Predicting Lower Extremity Deep Venous Thrombosis after Craniocerebral Trauma Surgery
摘要
Abstract
Objective:To explore and analyze the association between changes of neutrophil(NE)and coagulation parameters and lower extremity deep venous thrombosis(DVT)in patients after craniocerebral trauma surgery.Methods:A total of 105 patients with craniocerebral trauma in the hospital were enrolled from April 2021 to April 2024.The changes of NE,four coagulation indexes and D-dimer(D-D)were measured after surgery.Logistic regression analysis was used to analyze the related factors affecting the occurrence of lower extremity DVT,and receiver operating characteristic curve(ROC)was drawn to evaluate the predictive efficiency of NE and coagulation parameters on lower extremity DVT.Results:The thrombin time(TT),pro-thrombin time(PT)and activated partial prothrombin time(APTT)of lower extremity DVT patients after craniocerebral trauma surgery were significantly shorter than those of non-DVT patients(P<0.05),and the levels of NE,fibrinogen(FIB)and D-D were significantly higher(P<0.05).The proportion of tracheotomy in DVT patients was higher than that in non-DVT patients,and the surgical time was longer than that in non-DVT patients(P<0.05).Logistic regression analysis suggested that tracheotomy,surgical time,NE,PT,FIB and D-D were the risk factors affecting postoperative lower extremity DVT(P<0.05).ROC curve indica-ted that the AUCs of NE,PT,FIB and D-D in evaluating lower extremity DVT were 0.787,0.769,0.707 and 0.779 respectively.The AUC of the combination of the four indexes in assessing lower extremity DVT was 0.958,and the sensitivity and specificity under the maximum Youden index were 0.962 and 0.899 respec-tively.Conclusion:The abnormal changes of coagulation parameters such as NE,PT,FIB and D-D in pa-tients after craniocerebral trauma surgery are related to the risk of lower extremity DVT,and the combination of NE,PT,FIB and D-D has high predictive value on lower extremity DVT.关键词
颅脑外伤/深静脉血栓/中性粒细胞/凝血参数/预测价值Key words
Craniocerebral trauma/Deep venous thrombosis/Neutrophil/Coagulation parame-ters/Predictive value引用本文复制引用
汤厅均,彭古涛,肖文峰,廖鹏,汪峰..中性粒细胞联合凝血参数预测颅脑外伤术后下肢深静脉血栓的价值分析[J].河北医学,2024,30(11):1834-1839,6.基金项目
重庆市自然科学基金面上项目,(编号:CSTB2023NSCQ-MSX0246) （编号:CSTB2023NSCQ-MSX0246）
