河北医学2024，Vol.30Issue(11)：1839-1844,6.DOI:10.3969/j.issn.1006-6233.2024.11.015
老年急性脑梗死患者Hcy ApoB/ApoAⅠ及动态动脉硬化指数与颈动脉斑块性质的关系分析
Relationship between Hcy ApoB/ApoAⅠand Ambulatory Arterial Stiffness Index and Carotid Plaque Properties in Elderly Patients with Acute Cerebral Infarction
摘要
Abstract
Objective:To observe the relationship between changes of homocysteine(Hcy),apolipopro-tein B(ApoB)/apolipoprotein AⅠ(ApoAⅠ)and ambulatory arterial stiffness index(AASI)and carotid plaque properties in elderly patients with acute cerebral infarction(ACI).Methods:A total of 103 elderly patients with ACI(61 cases of stable plaque and 42 cases of unstable plaque)admitted to hospital from July 2021 to July 2023 were included.The Hcy,ApoB/ApoAⅠand AASI were observed.The relationship be-tween Hcy,ApoB,ApoAⅠ,AASI and carotid plaque properties was analyzed by univariate analysis and mul-tivariate Logistic regression analysis,and receiver operating characteristic curve(ROC)was plotted to analyze the evaluated efficiency of the three indicators on carotid plaque properties.Results:The Hcy,ApoB/ApoAⅠ,AASI and carotid intima-media thickness(IMT)in unstable plaque group were significantly higher than those in stable plaque group(P<0.05).Pearson correlation showed that Hcy,ApoB/ApoAⅠand AASI were positively correlated with IMT,showing statistical significance(r=0.354,0.372,0.390,P<0.05).Univa-riate analysis suggested that hypertension,diabetes mellitus and hyperlipidemia were related to the carotid plaque properties(P<0.05).Multivariate Logistic regression analysis revealed that hypertension,diabetes mellitus,hyperlipidemia,Hcy,ApoB/ApoAⅠ,and AASI were risk factors affecting the carotid plaque prop-erties(P<0.05).ROC analysis showed that the AUCs of Hcy,ApoB/ApoAⅠ and AASI in evaluating the carotid plaque properties were 0.696,0.711 and 0.764 respectively.The AUC of the combined evaluation of the three indicators was the highest(0.853),and the sensitivity and specificity under the maximum Youden index were 0.952 and 0.607 respectively.Conclusion:The changes of Hcy,ApoB/ApoAⅠ and AASI in elderly patients with ACI are related to the carotid plaque properties,and have certain evaluated value on un-stable plaque.关键词
急性脑梗死/颈动脉斑块/同型半胱氨酸/动脉硬化指数/载脂蛋白B/载脂蛋白AⅠKey words
Acute cerebral infarction/Carotid plaque/Homocysteine/Arterial stiffness index/Apolipoprotein B/Apolipoprotein AⅠ引用本文复制引用
王国珍,郝井兰,张成刚..老年急性脑梗死患者Hcy ApoB/ApoAⅠ及动态动脉硬化指数与颈动脉斑块性质的关系分析[J].河北医学,2024,30(11):1839-1844,6.基金项目
2022年安徽省重点研究与开发计划项目,(编号:2022e07020001) （编号:2022e07020001）
