透明细胞性肾细胞癌与乳头状肾细胞癌的临床病理特点免疫组化特征和预后分析OACSTPCD

Objective:To analyze the clinicopathological features,immunohistochemical features and prognosis of clear cell renal cell carcinoma(CCRCC)and papillary renal cell carcinoma(PRCC).Methods:The clinical data of 80 patients with renal cell carcinoma in the hospital from April 2021 to April 2023 were retrospectively analyzed.According to the pathological results,the patients were divided into CCRCC group(n=50)and PRCC group(n=30).The basic data,clinicopathological features and immunohistochemical features were compared between the two groups.All patients received surgical treatment and were followed up after discharge.The survival status at 1 year after surgery was counted and compared.Results:The hematuria ratio in CCRCC group was lower than that in PRCC group(P<0.05).There were no statistical differences in tumor diameter,T staging,N staging,M staging,renal envelope invasion and Fuhrman grading between CCRCC group and PRCC group(P>0.05).The positive rate of CD10 in CCRCC group was higher than that in PRCC group(P<0.05)while the positive rate of CK7 was lower than that in PRCC group(P<0.05),but the positive rates of PAX-8,TFE-3 and Vimentin revealed no statistical differences between CCRCC group and PRCC group(P>0.05).There was no statistical significance in survival status at 1 year after surgery in CCRCC group compared to PRCC group(P>0.05).Conclusion:There are differences in hematuria and im-munohistochemical CD10 and CK7 positive expressions between CCRCC patients and PRCC patients,and the short-term prognosis is similar.