河北医学2024，Vol.30Issue(11)：1858-1862,5.DOI:10.3969/j.issn.1006-6233.2024.11.019
探讨儿童过敏性紫癜中ASO阳性与阴性患儿的临床及实验室特征差异
Differences of Clinical and Laboratory Features between Positive andNnegative ASO in Children with Henoch-Schonlein Purpura
摘要
Abstract
Objective:To explore the correlation between streptococcal infections and the various classi-fications of Henoch-Schönlein Purpura(HSP)in children,focusing on associated clinical and laboratory pa-rameters.Methods:From January 2021 to December 2023,78 children diagnosed with HSP at Nanjing Gao-chun People's Hospital were enrolled.They were divided into ASO positive and ASO negative groups for anal-ysis of incidence rates and laboratory indicators.The children were further classified based on clinical manifes-tations into simple,joint,abdominal,renal,and mixed types.Additionally,50 healthy children undergoing routine physical examinations at the same hospital were included as controls.Serum samples from all partici-pants were tested for IgG and IgM antibodies,C4 complement levels,and throat swab cultures were performed to determine the relationship between streptococcal infection and HSP types.Results:The ASO positive group,generally older,showed significantly higher serum albumin levels(26.73±5.22 g/L)than the ASO negative group(23.45±4.88 g/L)(P<0.05),with no marked differences in urea and creatinine levels between the groups(P>0.05).Among immunoglobulin and complement levels,only IgA showed significant differences(P<0.05).IgG levels did not significantly vary among different HSP subtypes compared to controls,while IgM levels displayed significant differences(P<0.05).C4 levels were consistent across subtypes and controls(P>0.05).In terms of streptococcal types,type B hemolytic streptococcus appeared in 2.00%of the control group,and grass green streptococcus in 50.00%.Each HSP subtype had a distinct distribution of these bacte-ria,with type B hemolytic and grass green streptococci showing variable prevalence among the joint,abdomi-nal,renal,and mixed types.Conclusion:This study substantiates a significant link between streptococcal in-fections and the subtypes of allergic purpura(HSP)in pediatric patients.The association of ASO titers with specific clinical features and laboratory markers underscores the critical role of streptococcal infection consider-ation in the diagnostic and treatment strategies for HSP.This underscores the need for vigilant monitoring and management of streptococcal infections to optimize outcomes for children with HSP.关键词
抗链球菌溶血素O/儿童过敏性紫癜/链球菌/相关性Key words
Pediatric allergic purpura/Streptococcus/Anti streptococcal hemolysin O/Associ-ation引用本文复制引用
张会品,张建春..探讨儿童过敏性紫癜中ASO阳性与阴性患儿的临床及实验室特征差异[J].河北医学,2024,30(11):1858-1862,5.基金项目
江苏省自然科学基金项目,(编号:BK20211385) （编号:BK20211385）
