河北医学2024，Vol.30Issue(11)：1913-1917,5.DOI:10.3969/j.issn.1006-6233.2024.11.030
阿替普酶静脉溶栓治疗发病4.5h内脑卒中患者出院后第90天临床结局的相关因素分析
Related Factors of Clinical Outcomes on the 90th Day after Discharge in Patients with Stroke Treated by Intravenous Thrombolysis with Alteplase within 4.5 Hours of Onset
摘要
Abstract
Objective:To analyze the related factors of clinical outcomes on the 90th day after discharge in patients with stroke treated by alteplase(rt-PA)intravenous thrombolysis within 4.5 hours of onset.Methods:From January 2021 to February 2024,87 patients with stroke within 4.5 hours of onset who re-ceived rt-PA intravenous thrombolysis in the hospital were selected as the research subjects.According to the 90-day modified Rankin scale(mRS)evaluation results,they were divided into poor outcome group(mRS>2 points,n=31)and good outcome group(mRS≤2 points,n=56).Univariate analysis was used to analyze the influencing factor affecting the poor clinical outcomes on the 90th day after discharge.Multivariate Logistic regression analysis was applied to analyze the independent risk factors leading to the poor clinical outcomes.Results:Univariate analysis showed that compared with the good outcome group,the poor outcome group had longer onset to thrombolysis time(ONT)and admission to thrombolysis time(DNT),higher pre-thrombolysis National Institutes of Health Stroke Scale(NIHSS)score,lower early Alberta Stroke Project CT(ASPECTS)score,higher probabilities of hypertension and anterior circulation infarction and higher lipoprotein(a)level(P<0.05).Multivariate Logistic regression analysis found that long ONT(95%CI:1.030-1.195),long DNT(95%CI:1.031-1.182)and high NIHSS score before thrombolysis(95%CI:1.052-1.192)were in-dependent risk factors for poor clinical outcomes on the 90th day after discharge in stroke patients after the treatment of rt-PA intravenous thrombolysis within 4.5 hours of onset(P<0.05).Conclusion:ONT,DNT,and pre-thrombolysis NIHSS score are significantly correlated with the clinical outcomes on the 90th day after discharge in stroke patients within 4.5 hours of onset,and they are all independent risk factors for poor clini-cal outcomes on the 90th day after discharge.关键词
阿替普酶/脑卒中/静脉溶栓/临床结局/风险因素Key words
Alteplase/Stroke/Intravenous thrombolysis/Clinical outcomes/Risk factors引用本文复制引用
李波,童洋萍,云宗金..阿替普酶静脉溶栓治疗发病4.5h内脑卒中患者出院后第90天临床结局的相关因素分析[J].河北医学,2024,30(11):1913-1917,5.基金项目
湖南省卫生健康委2020年度科研立项课题,(编号:20201928) （编号:20201928）
