安石榴苷调节PI3K/Akt/mTOR信号通路对急性髓系白血病细胞自噬和凋亡的影响OACSTPCD
Effect of Punicalagin on Autophagy and Apoptosis in Acute Myeloid Leukemia Cells by Regulating the PI3K/Akt/mTOR Signaling Pathway
目的:探讨安石榴苷(PUN)调节磷脂酰肌醇 3-激酶(PI3K)/蛋白激酶 B(Akt)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路对急性髓系白血病(AML)细胞自噬和凋亡的影响.方法:体外培养人AML细胞(HL-60),随机分为Control 组(正常培养)、L-PUN、M-PUN、H-PUN 组(20、40、60μg/mL PUN)、740Y-P 组(60μg/mL PUN+30μmoL/L PI3K/Akt/mTOR信号通路激活剂 740Y…查看全部>>
Objective:To investigate the effect of punicalagin(PUN)on autophagy and apoptosis in a-cute myeloid leukemia(AML)cells by regulating the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR)signaling pathway.Methods:Human AML cells(HL-60)were cultured in vitro and randomly separated into control group(normal culture),L-PUN,M-PUN,H-PUN groups(20,40,60 μg/mL PUN),and 740 Y-P group(60 μg/mL PUN+30 μmol/L PI3K/Akt/mTOR sig…查看全部>>
常凤;张琳琳
河北省张家口市第一医院输血科,河北 张家口 075000河北省张家口市第一医院输血科,河北 张家口 075000
安石榴苷磷脂酰肌醇3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白信号通路急性髓系白血病细胞凋亡自噬
PunicalaginPhosphatidylinositol 3-kinase/protein kinase B/mammalian target of ra-pamycin signaling pathwayAcute myeloid leukemiaCell apoptosisAutophagy
《河北医学》 2024 (11)
1761-1766,6
河北省中医药管理局科研计划项目,(编号:2019538)
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