中药治疗在复发性口腔溃疡患者中的应用效果及对炎症因子的影响OA
Effect of Chinese medicine on recurrent oral ulcer and its influence on in-flammatory factors
目的 探讨中药治疗复发性口腔溃疡所取得的效果及对炎症因子的影响.方法 选取2022年3月至2023年12月云南省昭通市中医医院收治的80例复发性口腔溃疡患者作为研究对象,按照随机数字表法分为对照组(40例)和观察组(40例).对照组采用常规西药治疗,观察组采用中药治疗.比较两组临床疗效、溃疡面积、充血面积、视觉模拟评分(VAS)、口腔溃疡平均愈合时间以及炎症因子水平情况.结果 观察组临床总疗效高于对照组,差异有统计学意义(P＜0.05).治疗后,两组的溃疡面积、充血面积、VAS评分低于本组治疗前,其中,观察组上述各指标低于对照组,差异有统计学意义(P＜0.05).观察组口腔溃疡平均愈合时间短于对照组,差异有统计学意义(P＜0.05).治疗后,两组的肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)水平低于本组治疗前,白细胞介素-2(IL-2)水平高于本组治疗前,且观察组TNF-α、IL-8水平低于对照组,IL-2水平高于对照组,差异有统计学意义(P＜0.05).结论 复发性口腔溃疡患者在接受中药治疗后,炎症因子水平下降,溃疡面积缩小,愈合时间缩短,有效减轻了患者疼痛感,治疗效果显著.
Objective To investigate the effect of Chinese medicine on recurrent oral ulcer and its influence on inflammato-ry factors.Methods A total of 80 patients with recurrent oral ulcers from Zhaotong Hospital of Traditional Chinese Medicine in Yunnan Province from March 2022 to December 2023 were selected as the study objects and they were divided into con-trol group(40 cases)and observation group(40 cases).The control group was treated with conventional western medicine,and observation group was treated with traditional Chinese medicine treatment.The clinical efficacy,ulcer area,congestion area and visual analogue scale(VAS),the mean healing time of oral ulcer and the level of inflammatory factors were com-pared between the two groups.Results The total clinical efficacy of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).The ulcer area,congestion area and VAS score of the two groups after treatment were lower than those of the same group before treatment,and the above indicators of the observation group were lower than those of the control group,and the differences were statistically significant(P＜0.05).The average healing time of oral ulcer in the observation group was shorter than that in the control group,and the difference was statistically significant(P＜0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α)and interleukin-8(IL-8)in two groups were lower than those of the same group before treatment,and the levels of interleukin-2(IL-2)were higher than those of the same group before treatment,and the levels of TNF-α and IL-8 in observation group were lower than those of control group,and the levels of IL-2 were higher than those of control group,and the differences were statistically significant(P＜0.05).Conclusion After the treatment of recurrent oral ulcer,the level of inflammatory factors decreased significantly,the area of ulcer was significantly reduced,the healing time was significantly shortened,and the pain sense of patients was effectively reduced.
张克邪;涂泽耀
云南省昭通市中医医院口腔科,云南昭通 657000云南省昭通市中医医院脾胃病科,云南昭通 657000
口腔医学
复发性口腔溃疡中药治疗临床疗效炎症因子
Recurrent oral ulcersTraditional Chinese medicine treatmentClinical efficacyInflammatory factor
《中国当代医药》 2024 (033)
100-103 / 4
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