临床肝胆病杂志2024，Vol.40Issue(11)：2158-2163,6.DOI:10.12449/JCH241105
妊娠期抗病毒治疗阻断HBV母婴传播的新进展
New advances in antiviral therapy during pregnancy to block mother-to-child transmission of hepatitis B virus
摘要
Abstract
Mother-to-child transmission of hepatitis B virus(HBV)is one of the primary causes of the high disease burden of chronic hepatitis B in China,and blocking this route of transmission has an important strategic significance for eliminating hepatitis B.While immediate combined immunoprophylaxis for neonates upon birth is the fundamental strategy to block the mother-to-child transmission of HBV,there is still a mother-to-child transmission rate of 9%in mothers with high viral loads.In recent years,breakthroughs have been made in the research on antiviral therapy during pregnancy for blocking mother-to-child transmission,which marks a pivotal milestone in eliminating the mother-to-child transmission of hepatitis B.Comprehensive prophylaxis of antiviral therapy during pregnancy and immunoprophylaxis for infants after birth has become the key strategy for eliminating the mother-to-child transmission of hepatitis B.This article summarizes the development and latest advances in antiviral therapy during pregnancy for blocking mother-to-child transmission,as well as related intervention strategies and indications,in order to provide a reference for clinicians and public health physicians.关键词
乙型肝炎病毒/传染性疾病传播,垂直/孕妇Key words
Hepatitis B Virus/Infectious Diseases Transmission,Vertical/Pregnant Women引用本文复制引用
韩国荣,江红秀..妊娠期抗病毒治疗阻断HBV母婴传播的新进展[J].临床肝胆病杂志,2024,40(11):2158-2163,6.基金项目
国家"十三五"重大传染病防治科技专项(2017ZX10201201-001-002,2017ZX10201201-002-001) （2017ZX10201201-001-002,2017ZX10201201-002-001）
江苏省医学创新团队项目(CXTDA2017040) "13th Five-year"National Science and Technology Major Project for Infectious of China"(2017ZX10201201-001-002,2017ZX10201201-002-001) （CXTDA2017040）
Medical Innovation Team Project of Jiangsu Province(CXTDA2017040) （CXTDA2017040）
