临床肝胆病杂志2024，Vol.40Issue(11)：2168-2172,5.DOI:10.12449/JCH241107
HBV母婴传播的分子病毒学机制
Molecular virological mechanism of the mother-to-child transmission of hepatitis B virus
摘要
Abstract
Chronic hepatitis B virus(HBV)infection is a major global public health threat.In areas with moderate to high prevalence of HBV,mother-to-child transmission(MTCT)remains the main source of chronic HBV infection.With the application of combined immunization of hepatitis B vaccine and hepatitis B immunoglobulin in neonates,there has been a significant reduction in the incidence rate of HBV MTCT,but there is still a high risk of HBV MTCT in infants born to mothers with positive HBeAg and high viral loads.Although antiviral therapy for pregnant women with high HBV viral loads in late pregnancy can further reduce the risk of HBV MTCT,it is still difficult to completely block HBV MTCT.A deep understanding of the molecular virological mechanisms of HBV MTCT can provide clear ideas for blocking HBV MTCT,which is of great significance for the prevention and management of HBV MTCT.关键词
乙型肝炎病毒/传染性疾病传播,垂直/基因型Key words
Hepatitis B Virus/Infectious Disease Transmission,Vertical/Genotype引用本文复制引用
宋亚荣,王杰,李杰..HBV母婴传播的分子病毒学机制[J].临床肝胆病杂志,2024,40(11):2168-2172,5.基金项目
国家重点研发计划(2023YFC2306902) （2023YFC2306902）
国家自然科学基金(82172251) National Key Research and Development Program of China(2023YFC2306902) （82172251）
National Natural Science Foundation of China(82172251) （82172251）
