临床肝胆病杂志2024，Vol.40Issue(11)：2300-2305,6.DOI:10.12449/JCH241126
内质网应激在非酒精性脂肪性肝病中的作用及相关靶向治疗
The role of endoplasmic reticulum stress in non-alcoholic fatty liver disease and related targeted therapies
摘要
Abstract
Non-alcoholic fatty liver disease(NAFLD)is a series of diseases characterized by hepatic steatosis and is also a metabolism-associated disease and an important factor for liver fibrosis,liver cirrhosis,and hepatocellular carcinoma.Endoplasmic reticulum is a core organelle for the regulation of lipid metabolism,and unfolded protein response is an important process of endoplasmic reticulum stress(ERS).Based on the important stress role of endoplasmic reticulum in metabolism-associated diseases,this article explores the influencing mechanism between ERS and NAFLD and reviews the research advances in lipid metabolism,inflammatory response,hepatocyte death,fibrosis,and ERS-targeted therapies in the pathological development of NAFLD.关键词
非酒精性脂肪性肝病/内质网应激/非折叠蛋白质应答/分子靶向治疗Key words
Non-alcoholic Fatty Liver Disease/Endoplasmic Reticulum Stress/Unfolded Protein Response/Molecular Targeted Therapy引用本文复制引用
李岫滟,雷娜,宋虹霏,曾玲,王东,穆杰..内质网应激在非酒精性脂肪性肝病中的作用及相关靶向治疗[J].临床肝胆病杂志,2024,40(11):2300-2305,6.基金项目
国家自然科学基金青年项目(82104655) （82104655）
四川省自然科学基金面上项目(2024NSFSC0692) Youth Fund of National Natural Science Foundation of China(82104655) （2024NSFSC0692）
General Project of National Science Foundation of Sichuan Province(2024NSFSC0692) （2024NSFSC0692）
