临床肝胆病杂志2024，Vol.40Issue(11)：2320-2325,6.DOI:10.12449/JCH241129
肿瘤坏死因子α在肝细胞癌发生发展中的作用
The role of tumor necrosis factor-α in the development and progression of hepatocellular carcinoma
摘要
Abstract
Tumor necrosis factor-α(TNF-α)is involved in the regulation of multiple biological processes such as the proliferation,invasion,migration,and chemotherapy resistance of hepatocellular carcinoma(HCC)cells through TNF receptor-mediated signaling pathways.At the same time,TNF-α also plays a role in inducing the apoptosis of HCC cells.Some TNF-α inhibitors have been shown to inhibit the progression of HCC and prolong survival time.At present,the potential mechanism of action of TNF-α in HCC remains unclear,and exploration of the interaction between TNF-α and HCC can help to determine the potential therapeutic targets for HCC.This article summarizes the latest research advances in the mechanism of action of TNF-α in HCC and introduces the possibility of targeting TNF-α as a treatment method for HCC,in order to provide a theoretical basis for the prevention and treatment of liver cancer and drug research and development.关键词
癌,肝细胞/肿瘤坏死因子α/信号传导/分子靶向治疗Key words
Carcinoma,Hepatocellular/Tumor Necrosis Factor-alpha/Signal Transduction/Molecular Targeted Therapy引用本文复制引用
朱玲玲,张亚妮,史婷婷,伍杨,高春,于晓辉,何昱静,张久聪..肿瘤坏死因子α在肝细胞癌发生发展中的作用[J].临床肝胆病杂志,2024,40(11):2320-2325,6.基金项目
中央高校优秀青年团队培育项目(31920220065) （31920220065）
甘肃省卫生健康行业科研计划项目(GSWSKY2022-76) （GSWSKY2022-76）
甘肃省科技计划项目(23JRRA1673) Central University Excellent Youth Team Cultivation Project(31920220065) （23JRRA1673）
Gansu Province Health Industry Scientific Research Plan Project Contract(GSWSKY2022-76) （GSWSKY2022-76）
Gansu Planning Project on Science and Technology(23JRRA1673) （23JRRA1673）
