肿瘤预防与治疗2024，Vol.37Issue(11)：945-953,9.DOI:10.3969/j.issn.1674-0904.2024.11.004
2020～2023年河南省肠癌Septin9基因甲基化分布特征
Distribution of Septin9 Gene Methylation in Colorectal Cancer in Henan Province from 2020 to 2023
王紫薇 1刘永生 2朱丽蒙 1张暋 1赵哲 1王晓南 1马吉芬 1王小乐 1韩雪莹 1岳文兵1
作者信息
- 1. 450000 郑州,河南郑州金域临床检验中心
- 2. 450002 郑州,河南省中医院(河南中医药大学第二附属医院)健康管理中心
- 折叠
摘要
Abstract
Objective:To characterize the age,regional distribution and clinical characteristics of colorectal cancer pa-tients with Septin9 gene methylation in Henan Province,construct a early-screening risk model,and provide suggestions for clinical early screening of colorectal cancer.Methods:Septin9 gene methylation data from 20,707 cases of colorectal cancer from 2020 to 2023 was retrospectively analyzed,and the model was simulated by chi-square test and nonlinear algorithm.Re-sults:The overall positive rate of Septin9 gene methylation in colorectal cancer was 2.66％in 20,707 physical examination samples.Test samples were separated by age group,the number of positive samples peak in the 50～60 age group(6,087 cases,29.4％),with the highest risk rate in the 80～90 age group(5.37,P＜0.001).The number of tests varied between seasons with the highest in winter.However,there was no significant difference in positive rates between seasons(P＞0.05).The positive rate of methylation detection in central cities such as Zhengzhou,Xuchang and Kaifeng was higher than that in remote cities,and that in the central region was higher than that in the north region,and that in the north region was higher than that in the west region.The positive rate of males was 2.83 which was significantly higher than that of females(2.19,P＜0.001).It was found that the risk of methylation at the ages of 63.27,74.54 and 85.82 were larger than that at the age of 20 by 1.5 times,2 times and 3 times.Conclusion:This study established the first regional age-gene methyla-tion risk model for Henan Province,which provides important guidance for the clinical early screening of colorectal cancer.关键词
河南省/肠癌/Septin9基因甲基化/分布特征/风险因素/风险模型Key words
Henan Province/Bowel cancer/Methylation of Septin9 gene/Characteristics of distribution/Risk factor/Risk model分类
医药卫生引用本文复制引用
王紫薇,刘永生,朱丽蒙,张暋,赵哲,王晓南,马吉芬,王小乐,韩雪莹,岳文兵..2020～2023年河南省肠癌Septin9基因甲基化分布特征[J].肿瘤预防与治疗,2024,37(11):945-953,9.
