2020～2023年河南省肠癌Septin9基因甲基化分布特征OACSTPCD

Objective:To characterize the age,regional distribution and clinical characteristics of colorectal cancer pa-tients with Septin9 gene methylation in Henan Province,construct a early-screening risk model,and provide suggestions for clinical early screening of colorectal cancer.Methods:Septin9 gene methylation data from 20,707 cases of colorectal cancer from 2020 to 2023 was retrospectively analyzed,and the model was simulated by chi-square test and nonlinear algorithm.Re-sults:The overall positive rate of Septin9 gene methylation in colorectal cancer was 2.66％in 20,707 physical examination samples.Test samples were separated by age group,the number of positive samples peak in the 50～60 age group(6,087 cases,29.4％),with the highest risk rate in the 80～90 age group(5.37,P＜0.001).The number of tests varied between seasons with the highest in winter.However,there was no significant difference in positive rates between seasons(P＞0.05).The positive rate of methylation detection in central cities such as Zhengzhou,Xuchang and Kaifeng was higher than that in remote cities,and that in the central region was higher than that in the north region,and that in the north region was higher than that in the west region.The positive rate of males was 2.83 which was significantly higher than that of females(2.19,P＜0.001).It was found that the risk of methylation at the ages of 63.27,74.54 and 85.82 were larger than that at the age of 20 by 1.5 times,2 times and 3 times.Conclusion:This study established the first regional age-gene methyla-tion risk model for Henan Province,which provides important guidance for the clinical early screening of colorectal cancer.