肿瘤预防与治疗2024，Vol.37Issue(11)：979-985,7.DOI:10.3969/j.issn.1674-0904.2024.11.008
基于磁共振放疗平台模拟胰腺癌不同配准策略的研究
Simulation of Different Alignment Strategies for Pancreatic Cancer Based on MRI-Guided Radiotherapy Platform
摘要
Abstract
Objective:To investigate the differences among bone alignment,skin surface alignment and tumor alignment for adaptive radiotherapy of pancreatic cancer with a magnetic resonance accelerator,and provide evidence for precision ra-diotherapy alignment strategies for pancreatic cancer.Methods:From November 2021 to April 2023,16 patients with pancreatic cancer treated with a Unity magnetic resonance accelerator at Sichuan Cancer Hospital were selected.MR im-ages were obtained before each radiotherapy session,and were registered with planned CT images.Alignment was performed in three ways,bone,patient's body surface,and actual tumor.Setup errors in the left-right(X axis),superior-inferior(Y axis)and anterior-posterior(Z axis)directions were obtained.The differences between the two alignment methods and the tumor alignment were compared.The results were expressed in ab-solute values,and the statistical difference between the two groups and the tumor alignment was calculated.The frequency of displacement values was counted to verify the clinical stability.Results:A total of 92 radiotherapy sessions were performed in 16 patients.The differences in the X,Y and Z directions in the bone alignment group were(1.12±0.90)mm,(2.01±2.12)mm and(0.10±0.84)mm,the differences in the X,Y and Z directions were(1.64±1.28)mm,(3.48±2.29)mm and(3.94±2.76)mm in the skin surface alignment group.Differences between tumor alignment and skin surface a-lignment were statistically significant in X and Z axes.The frequency of error greater than 5 mm in the Y-axis direction in the bone alignment strategy was 14.13％,while the skin surface alignment strategy had errors greater than 5 mm of different fre-quency in the X,Y and Z directions(1％in the X direction,16.3％in the Y direction and 29.35％in the Z direction).Conclusion:Bone alignment is more reliable in image-guided radiotherapy for pancreatic cancer.However,it is shown that there are substantial differences in the superior-inferior direction.Therefore,individual treatment strategies should be consid-ered for radiotherapy in pancreatic cancer.关键词
磁共振加速器/胰腺癌/图像引导放疗/配准策略Key words
Magnetic resonance accelerator/Pancreatic cancer/Image-guided radiation therapy/Alignment strategy分类
医药卫生引用本文复制引用
郑人川,李林涛,郎锦义,刘敏,刘亚昕,王先良,牛刚,方曾怡,杨凤,辛欣,王伊玲..基于磁共振放疗平台模拟胰腺癌不同配准策略的研究[J].肿瘤预防与治疗,2024,37(11):979-985,7.基金项目
This study was supported by Natural Science Foundation of Sichuan Province(No.2023NSFSC0711)and Sichuan Cadre Health Research Project(No.ZH2023-801). 四川省自然科学基金(编号:2023NSFSC0711) （No.2023NSFSC0711）
四川省干部保健科研课题(编号:ZH2023-801) （编号:ZH2023-801）
