中风与神经疾病杂志2024，Vol.41Issue(11)：982-987,6.DOI:10.19845/j.cnki.zfysjjbzz.2024.0187
血清NFL、GFAP水平与帕金森病患者焦虑抑郁的相关性研究
Association of the serum levels of neurofilament light chain and glial fibrillary acidic protein with anxiety and de-pression in patients with Parkinson disease
摘要
Abstract
Objective To investigate the association of serum neurofilament light chain(NFL)and glial fibrillary acidic protein(GFAP)with Parkinson disease(PD)with anxiety and depression.Methods A total of 96 PD patients and 38 healthy controls were enrolled in this study.Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD)were used to evaluate anxiety and depression in the PD patients,and the patients were divided into groups based on their diseases.Ultrasensitive single molecule array(Simoa)was used to quantitatively measure the serum levels of NFL and GFAP.The levels of NFL and GFAP were compared between groups;Spearman correlation analysis and logistic re-gression analysis were used to investigate the association of NFL and GFAP with anxiety and depression in PD patients;the receiver operating characteristic(ROC)curve was used to access the value of GFAP level in the diagnosis of PD with de-pression.Results Compared with the healthy control group,the PD patients with or without anxiety and depression had a significant increase in the level of NFL(P＜0.001),and compared with the PD patients without depression or anxiety,the PD patients with depression or anxiety had a significant increase in the level of GFAP(P＜0.05).In the PD patients,the serum level of GFAP was positively correlated with the degree of anxiety(r=0.271,P=0.008)and depression(r=0.302,P=0.003).After adjustment for confounding factors,the logistic regression analysis showed that GFAP remained an inde-pendent risk factor for depression in PD patients(P=0.028).The ROC curve analysis showed that GFAP had an area un-der the ROC curve of 0.660 in the diagnosis of PD with depression.Conclusion Serum GFAP level is associated with anxiety and depression in PD and is an independent risk factor for PD with depression.关键词
帕金森病/神经丝轻链/胶质纤维酸性蛋白/焦虑/抑郁Key words
Parkinson disease/Neurofilament light chain/Glial fibrillary acidic protein/Anxiety/De-pression分类
临床医学引用本文复制引用
李杨丹钰,李富佳,刘旭,徐传英,崔桂云..血清NFL、GFAP水平与帕金森病患者焦虑抑郁的相关性研究[J].中风与神经疾病杂志,2024,41(11):982-987,6.基金项目
江苏省重点研发计划(社会发展)项目(BE2021630) （社会发展）
徐州市卫生健康委员会医学科技创新项目(XWKYHT20220158) （XWKYHT20220158）
徐州医科大学揭榜挂帅攻关项目(JBGS202203) （JBGS202203）
