中风与神经疾病杂志2024，Vol.41Issue(11)：993-998,6.DOI:10.19845/j.cnki.zfysjjbzz.2024.0189
多模态磁共振成像在帕金森病伴抑郁研究中的应用
Application of multimodal magnetic resonance imaging in the research on depression in Parkinson disease
摘要
Abstract
Depression is one of the most common and earliest non-motor symptoms of Parkinson disease(PD)and can significantly increase the burden on PD patients,caregivers,and society.Due to the neglect of non-motor symptoms in clinical diagnosis and treatment and the overlaps between depression and other symptoms of PD,there are serious defi-ciencies in the diagnosis or treatment of depression in PD,and therefore,it is of great significance to identify objective bio-markers for depression in PD and investigate their application value.The development of multimodal magnetic resonance imaging makes it possible to achieve this goal.Multimodal MRI has revealed a wide range of brain lesions in PD with de-pression,with similar pathological changes as primary depression,as well as specific abnormalities in brain structure and function.At present,there is still no exact pathological model for PD with depression,and multimodal MRI has promising application prospects in exploring the pathophysiological mechanisms of PD with depression and identifying the biomarkers for early diagnosis and monitoring.关键词
多模态磁共振成像/帕金森病/抑郁/生物标志物Key words
Multimodal magnetic resonance imaging/Parkinson disease/Depression/Biomarkers分类
医药卫生引用本文复制引用
王惠,马先军,徐剑霞,任静茹,郭志颖,刘卫国..多模态磁共振成像在帕金森病伴抑郁研究中的应用[J].中风与神经疾病杂志,2024,41(11):993-998,6.基金项目
国家重点研发计划重点专项(2017YFC1310302) （2017YFC1310302）
江苏省科技计划项目重点项目(BE2019611) （BE2019611）
连云港市科协软课题研究项目(Lkxyb23217) （Lkxyb23217）
