中风与神经疾病杂志2024，Vol.41Issue(11)：999-1003,5.DOI:10.19845/j.cnki.zfysjjbzz.2024.0190
帕金森病前驱期临床试验设计方法学的研究进展
Advances in clinical trial design methodology for prodromal Parkinson disease
摘要
Abstract
The neuropathic damage of Parkinson disease(PD)is irreversible.In recent years,advances in PD re-search frontiers have found that decades before the typical motor symptoms of PD,some pathological changes already hap-pen.This interval prior to diagnosis,or the prodromal phase of PD,is an excellent window for neuroprotective therapy re-search,and this type of research may create a breakthrough in developing effective treatment for PD,reducing the inci-dence of PD,and delaying the progression of PD.This review on prodromal PD-related literature summarizes current clini-cal research design methods,and discusses the decision-making around clinical trial design with regard to study popula-tion,sample size,outcome indicators,safety,and subject diaries,aiming to provide a reference for the design of clinical trials of prodromal PD.关键词
帕金森病/帕金森病前驱期/临床试验设计/策略选择Key words
Parkinson disease/Prodromal Parkinson disease/Clinical trial design/Strategy selection分类
医药卫生引用本文复制引用
张亚珂,王顺,王玉琳,白妍..帕金森病前驱期临床试验设计方法学的研究进展[J].中风与神经疾病杂志,2024,41(11):999-1003,5.基金项目
中华中医药学会求实项目中医药临床案例成果库建设专项(QSAL2022-016) （QSAL2022-016）
第四届国医大师传承工作室建设项目(国中医药办人教函[2022]245号) （国中医药办人教函[2022]245号）
