角膜神经移植术治疗神经营养性角膜病变的研究进展OA

Neurotrophic keratopathy is a disease related to degenerative changes in corneal nerves,resulting in impaired sensory and nutritive functions of corneal nerves.This leads to corneal epithelial defects,corneal ulcers,and corneal perforation.Currently,the main treatment modalities include pharmacotherapy,non-surgical interventions,and surgical treatment.However,drug therapy and non-surgical interventions often yield unsatisfactory results for severe neurotrophic keratopathy patients.Performing corneal transplantation in patients with unrecovered corneal sensation may result in persistent epithelial defect.Therefore,the restoration of corneal sensation is a crucial prerequisite for visual rehabilitation.Corneal neurotization emerges as an important and effective therapeutic approach for severe cases of neurotrophic keratopathy,aiming to restore corneal sensation and enhance corneal transparency.The procedure involves transplanting nerves from a donor with normal sensory function to the paralyzed sub-Tenon perilimbal space,allowing nerve endings to regenerate into the corneal stroma and restoring corneal sensory function.With continuous improvements in the technique of corneal neurotization,its favorable postoperative outcomes and advantages are becoming increasingly evident.This article,based on the team's experience in corneal neurotization,elaborates on the treatment modalities for neurotrophic keratopathy and the application and prospects of various surgical techniques in corneal neurotization.