中国防痨杂志2024，Vol.46Issue(12)：1490-1495,6.DOI:10.19982/j.issn.1000-6621.20240181
610例老年结核病患者临床分离株耐药情况分析
Analysis of drug resistance in clinical isolates from 610 elderly tuberculosis patients
摘要
Abstract
Objective:To analyze the drug resistance characteristics of clinical isolates of Mycobacterium tuberculosis(MTB)in elderly tuberculosis patients(≥60 years old)in a tuberculosis designated hospital in Lishui City,Zhejiang Province,China,offering insights for the prevention and control of drug-resistant tuberculosis in the elderly population of the region.Methods:Information on clinical isolates and samples from elderly tuberculosis patients visiting the Lishui Regional Tuberculosis Sentinel Hospital from 2018 to 2023 was collected.Resistance to first-line antituberculosis drugs(streptomycin,isoniazid,rifampicin,ethambutol)was detected using BACTEC MGIT 960 liquid drug susceptibility test and resistance characteristics were analyzed.Results:A total of 610 strains of MTB were included in the drug resistance detection and analysis.The overall drug resistance rate was 18.85％(115/610),and the multidrug resistance rate was 6.07％(37/610).The drug resistance rate of male patients was 19.38％(93/480),and that of female patients was 16.92％(22/130),with no statistically significant difference(x2=0.402,P＞0.05).The drug resistance rate among initial treatment patients was 18.18％(98/539),and that of retreated patients was 23.94％(17/71).Among them,the ethambutol resistance rate among retreated patients(8.45％(6/71))was significantly higher than that among initial treatment patients(2.78％(15/539),x2=6.063,P＜0.05).The resistance rates for different drugs ranked as:isoniazid(14.59％,89/610),streptomycin(8.85％,54/610),rifampicin(7.38％,45/610),and ethambutol(3.44％,21/610).The drug resistance patterns showed a total of 13 different drug resistance combinations.Among multidrug resistance combinations,the highest drug resistance rate was for"isoniazid+rifampicin+streptomycin"(2.62％,16/610).The drug resistance rate was 20.00％(19/95)in 2018 and 17.83％(23/129)in 2023,with no statistically significant difference for changing trend(x2trend=1.792,P＞0.05).Conclusion:The drug resistance rate of MTB in elderly tuberculosis patients in Lishui Region has decreased in the past years,but the drug resistance situation is still severe.关键词
分枝杆菌,结核/老年人/结核,抗多种药物性/药物敏感性试验Key words
Mycobacterium tuberculosis/The elderly/Tuberculosis,multidrug-resistant/Medicine sensitiveness test分类
医药卫生引用本文复制引用
许河南,赖聪娟,张尊敬,郭净,徐丽霞,张颖,刘忠达..610例老年结核病患者临床分离株耐药情况分析[J].中国防痨杂志,2024,46(12):1490-1495,6.基金项目
Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project(2023ZL801) （2023ZL801）
Science and Technology Department of the State Administration of Traditional Chinese Medicine-Zhejiang Provincial Administration of Traditional Chinese Medicine Co-construction Science and Technology Programme Project(GZY-ZJ-KJ-23096) 浙江省中医药科技计划项目(2023ZL801) （GZY-ZJ-KJ-23096）
国家中医药管理局-浙江中医药管理局共建科技计划项目(GZY-ZJ-KJ-23096) （GZY-ZJ-KJ-23096）
