中国防痨杂志2024，Vol.46Issue(12)：1496-1503,8.DOI:10.19982/j.issn.1000-6621.20240230
387名结核分枝杆菌潜伏感染者预防性治疗服药完成情况及影响因素分析
Analysis of treatment completeness and its influencing factors of preventive treatment among 387 latent tuberculosis infection cases
摘要
Abstract
Objective:To study the treatment completeness and its influencing factors of 3H-P preventive treatment among close contacts of tuberculosis patients with latent tuberculosis infection(LTBI)and to provide a reference for further promotion of preventive treatment.Methods:Between January 1,2023 and December 31,2023,387 LTBI cases who had close contact with tuberculosis patients and received preventive treatment with informed consent from Wushi County,Aksu Prefecture,Xinjiang Uygur Autonomous Region(Xinjiang)were enrolled as research subjects.A questionnaire was used to collect information of the completion of preventive treatment and its influencing factors,mainly including basic demographic information,awareness of tuberculosis prevention and control core knowledge,completion of preventive treatment,etc.Univariable and multivariable logistic regression were used to analyze the influencing factors related to the completion of preventive treatment.Results:Among 387 LTBI cases,355 completed preventive treatment,with a treatment completion rate of 91.73％.The incidence of adverse reactions was 14.21％(55/387),and 4.39％(17/387)of cases discontinued their treatment due to adverse reactions.Multivariable logistic regression analysis indicated that taking exercise regularly(OR=5.337,95％CI:2.309-12.337)and attending training on tuberculosis prevention and control(OR=4.406,95％CI:1.942-9.994)were protective factors for completion of preventive treatment,while a history of alcohol consumption(OR=0.279,95％CI:0.108-0.720)and aged 50-64 years(OR=0.254,95％CI:0.092-0.698)were risk factors for completion of treatment.Conclusion:Completion of preventive treatment among close contacts of tuberculosis patients with LTBI was generally good,with adverse reactions being one of the main reasons for interruption of treatment.The completion rate of their treatment was affected by not exercising regularly,history of alcohol consumption,not attending training on tuberculosis prevention and control,and aged 50-64 years.关键词
结核,肺/接触者追踪/抗结核药/预防和防护用药/因素分析,统计学Key words
Tuberculosis,pulmonary/Contact tracing/Antitubercular agents/Protective agents/Factor analysis,statistical分类
医药卫生引用本文复制引用
加依那提·金格斯,王新旗,刘年强,王森路,依帕尔·艾海提,冯建宇,黄涛,克地尔叶克孜·吾甫尔..387名结核分枝杆菌潜伏感染者预防性治疗服药完成情况及影响因素分析[J].中国防痨杂志,2024,46(12):1496-1503,8.基金项目
"Tianshan Talents"Medical and Health High-level Talent Training Program(TSYC202301B166) （TSYC202301B166）
Natural Science Foundation of Xinjiang Uygur Autonomous Region(2023D01C57) （2023D01C57）
Public Health Talent Training Project(01063JU) "天山英才"医药卫生高层次人才培养计划(TSYC202301B166) （01063JU）
新疆维吾尔自治区自然科学基金(2023D01C57) （2023D01C57）
公共卫生人才培养项目(01063局) （01063局）
