中国防痨杂志2024，Vol.46Issue(12)：1511-1518,8.DOI:10.19982/j.issn.1000-6621.20240273
重庆市利福平敏感肺结核患者的治疗转归及影响因素分析
Analysis of treatment outcomes and influencing factors of rifampicin-sensitive pulmonary tuberculosis patients in Chongqing City
摘要
Abstract
Objective:To analyze the treatment outcomes and risk factors of rifampicin-sensitive pulmonary tuberculosis(PTB)patients in Chongqing City,and to provide evidence for improving treatment management measures of patients and accurately evaluating treatment outcomes.Methods:A retrospective study was conducted to include a total of 11 545 rifampicin-sensitive PTB patients diagnosed and registered for treatment in Chongqing City in 2022 from the Chinese tuberculosis information management system(TBMIS).Basic demographic information and clinical data of the subjects were recorded and sorted out.Univariable and multivariable logistic regression models were used to analyze factors affecting treatment outcomes.Results:Treatment success rate of 11 545 rifampicin-sensitive PTB patients was 90.26％(10 421/11 545).Treatment failure rate was 0.72％(83/11 545),loss of follow-up rate was 1.49％(172/11 545),and mortality rate was 5.52％(637/11 545).Multivariable logistic regression analysis showed that ethnic minority(OR=1.573,95％CI:1.288-1.922),aged over 60 years old(60-74 years old:OR=3.322,95％CI:1.043-10.583;≥75 years old:OR=7.941,95％CI:2.490-25.323),etiologically positive(OR=1.419,95％CI:1.214-1.659),retreatment(OR=1.371,95％CI:1.121-1.677),severe pulmonary tuberculosis(OR=1.348,95％CI:1.108-1.639),adverse reactions(OR=4.183,95％CI:2.707-6.464),moderate and treated in secondary or lower institutions(OR=1.333,95％CI:1.161-1.532)were risk factors for treatment success.Being female(OR=0.659,95％CI:0.562-0.773)was a protective factor for treatment success.Conclusion:The treatment success rate of rifampicin-sensitive PTB patients in Chongqing City was about 90％,but special attention should be paid to patients who are ethnic minorities,over 60 years old,etiologically positive,retreatment,severe case,having adverse reactions,and treated in secondary and lower facilities.关键词
结核,肺/治疗效果/因素分析,统计学Key words
Tuberculosis,pulmonary/Treatment outcome/Factor analysis,statistical分类
医药卫生引用本文复制引用
余雅,陈健,徐飚,赵琦,吴成果,汪清雅,范君,钟吉元..重庆市利福平敏感肺结核患者的治疗转归及影响因素分析[J].中国防痨杂志,2024,46(12):1511-1518,8.基金项目
Chongqing Medical Scientific Research Project Joint Project of Chongqing Health Commission and Science and Technology Bureau(2023MSXM143) （2023MSXM143）
The Batch of Key Disciplines on Public Health in Chongqing(2022) 重庆市科卫联合医学科研项目(2023MSXM143) （2022）
重庆市公共卫生重点专(学)科建设项目(2022) （学）
