首页|期刊导航|中国药物经济学|左炔诺孕酮宫内缓释系统联合益血生胶囊治疗子宫腺肌症合并中度贫血的临床疗效

左炔诺孕酮宫内缓释系统联合益血生胶囊治疗子宫腺肌症合并中度贫血的临床疗效OA

Clinical Effect of Levonorgestrel Intrauterine Sustained Release System combined with Yixue Sheng Capsule in the Treatment of Uterine Adenomyosis complicated with Moderate Anemia

中文摘要英文摘要

目的 探讨左炔诺孕酮宫内缓释系统联合益血生胶囊治疗子宫腺肌症合并中度贫血的临床疗效.方法 选取2020年12 月至2023 年1 月于广州中医药大学附属中山市中医院妇产科就诊的子宫腺肌症合并中度贫血患者60 例为研究对象,所有患者均行宫腔放置左炔诺孕酮宫内缓释系统联合口服益血生胶囊治疗.观察患者用药前及用药1、2 个月后月经量、痛经改善情况及血红蛋白水平、子宫内膜变化、不良反应发生情况.结果 用药1、2 个月后患者的经量均出现不同程度的改善,2 个月后改善更明显,改善率分别为93.3%、98.3%;用药1、2 个月后患者的痛经均出现不同程度的缓解,2 个月后缓解更明显,缓解率分别为85.0%、90.0%;贫血方面用药1、2 个月纠正率分别为96.7%、100.0%;用药1、2 个月后患者子宫内膜厚度、阴道不规则出血发生率明显低于用药前,用药 2 个月后患者子宫内膜厚度、阴道不规则出血发生率明显低于用药 1 个月,差异有统计学意义(P<0.05).结论 左炔诺孕酮宫内缓释系统联合益血生胶囊治疗子宫腺肌症合并中度贫血可有效改善贫血症状,缓解痛经,减少经量,使子宫内膜厚度降低,且安全性较高.

Objective To explore the clinical effect of levonorgestrel intrauterine sustained release system combined with Yixue Sheng capsule in the treatment of uterine adenomyosis complicated with moderate anemia.Methods Sixty patients with uterine adenomyosis complicated with moderate anemia who were treated in the obstetrics and Gynecology Department of Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine from December 2020 to January 2023 were selected as the study objects.All patients were treated with intrauterine levonorgestrol intrauterine sustained release system combined with oral Yixue capsule.Menstrual volume,dysmenorrhea,mean hemoglobin value,endometrial changes and adverse reactions were observed before and after 1 and 2 months of medication.Results After 1 and 2 months of treatment,the menses of the patients were improved to varying degrees,and the improvement rate was 93.3%and 98.3%,respectively.After 1 and 2 months of treatment,the patients'dysmenorrhea was relieved to varying degrees,and the remission was more obvious after 2 months,with remission rates of 85.0%and 90.0%,respectively.The correction rates of anemia after 1 and 2 months were 96.7%and 100.0%,respectively.The incidence of endometrial thickness and irregular vaginal bleeding after 1 and 2 months of medication was significantly lower than that before medication,and the incidence of endometrial thickness and irregular vaginal bleeding after 2 months of medication was significantly lower than that after 1 month of medication,with statistical significance(P<0.05).Conclusion Levonorgestrel intrauterine sustained release system combined with Yixeshan capsule in the treatment of uterine adenomyosis complicated with moderate anemia can effectively improve the symptoms of anemia,relieve dysmenorrhea,reduce menstrual volume,and reduce endometrial thickness,with high safety.

郭伟红;麦华荣;冯嘉颖

广州中医药大学附属中山市中医院妇产科,广东 中山 528400广州中医药大学附属中山市中医院妇产科,广东 中山 528400广州中医药大学附属中山市中医院妇产科,广东 中山 528400

临床医学

左炔诺孕酮宫内缓释系统益血生胶囊子宫腺肌症贫血

Levonorgestrel intrauterine sustained release systemYixuesheng CapsuleUterine adenomyosisAnemia

《中国药物经济学》 2024 (11)

68-70,3

10.12010/j.issn.1673-5846.2024.11.013

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