超声清创联合重组人表皮生长因子对肛周脓肿合并感染患者创面愈合及肛门功能的影响OA
Effect of Ultrasonic Debridement combined with RhEGF on Wound Healing and Anal Function For Patients with Perianal Abscess complicated with Infection
目的 探讨超声清创联合重组人表皮生长因子(RhEGF)对肛周脓肿合并感染患者创面愈合及肛门功能的影响.方法 选取2022 年8 月至2023 年8 月南宁市第三人民医院收治的73 例肛周脓肿合并感染患者作为研究对象,按随机数字表法分为观察组(n=36)和对照组(n=37).对照组给予 RhEGF 治疗,观察组采用超声清创联合 RhEGF 治疗.比较两组腐肉脱落时间、上皮出现时间、创面愈合时间、创面细菌清除率、视觉模拟评分法(VAS)评分、经皮氧分压、创面血流量、括约肌最大收缩压、直肠静息压及肛管静息压.结果 观察组腐肉脱落时间、上皮出现时间及创面愈合时间短于对照组(P＜0.05);治疗1、3、7 d观察组创面细菌清除率高于对照组,治疗3、7 d观察组VAS评分低于对照组,差异有统计学意义(P＜0.05);治疗前,两组经皮氧分压、创面血流量比较差异无统计学意义(P＞0.05);治疗后,观察组经皮氧分压及创面血流量高于对照组(P＜0.05);治疗前,两组括约肌最大收缩压、直肠静息压及肛管静息压比较差异无统计学意义(P＞0.05);治疗后观察组括约肌最大收缩压及直肠静息压较对照组明显改善(P＜0.05),两组肛管静息压比较差异无统计学意义(P＞0.05).结论 超声清创联合RhEGF治疗肛周脓肿合并感染效果显著,可有效清除细菌,促进创面愈合,改善肛门功能.
Objective To explore the effect of ultrasonic debridement combined with recombinant human epidermal growth factor(RhEGF)on wound healing and anal function in patients with perianal abscess complicated with infection.Methods A total of 73 patients with perianal abscess combined with infection admitted to the Third People's Hospital of Nanning from August 2022 to August 2023 were selected as the study objects,and were divided into observation group(n=36)and control group(n=37)according to random number table method.The control group was treated with RhEGF,and the observation group was treated with ultrasonic debridement combined with RhEGF.The rotting time,epithelial time,wound healing time,wound bacterial clearance rate,VAS score,percutaneous partial pressure of oxygen,wound blood flow,maximum sphincter systolic pressure,rectal resting pressure and anal canal resting pressure were compared between the two groups.Results The time of rotting flesh shedding,epithelial appearance and wound healing in observation group were shorter than those in control group(P＜0.05).After 1,3 and 7 days of treatment,the wound bacterial clearance rate of observation group was higher than that of control group,and the VAS score of observation group was lower than that of control group,with statistical significance(P＜0.05).Before treatment,there was no significant difference in percutaneous partial pressure of oxygen and wound blood flow between the two groups(P＞0.05).After treatment,percutaneous partial pressure of oxygen and wound blood flow in observation group were higher than those in control group(P＜0.05).Before treatment,there was no significant difference in the maximum sphincter systolic pressure,rectal resting pressure and anal canal resting pressure between the two groups(P＞0.05).After treatment,the maximum sphincter systolic pressure and rectal resting pressure in the observation group were significantly improved compared with the control group(P＜0.05),and there was no statistical significance in the resting pressure of anal canal between the two groups(P＞0.05).Conclusion Ultrasonic debridement combined with RhEGF is effective in the treatment of perianal abscess complicated with infection,which can effectively remove bacteria,promote wound healing and improve anal function.
陆大卿;陆玉晶;覃晓虹
南宁市第三人民医院普外科,南宁 530003南宁市第三人民医院普外科,南宁 530003中国人民解放军联勤保障部队第九二三医院检验科,南宁 530021
临床医学
超声清创肛周脓肿重组人表皮生长因子微循环肛门功能
Ultrasonic debridementPerianal abscessRecombinant human epidermal growth factorMicrocirculationAnal function
《中国药物经济学》 2024 (11)
71-74,4
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