培门冬酶对急性淋巴细胞白血病患儿的疗效和凝血功能的影响OA

Objective To explore the clinical effect of PEG-Asp in the treatment of acute lymphoblastic leukemia(ALL)and its effect on coagulation function.Methods A total of 119 children with ALL who received treatment in Tai'an Maternal and Child Health Hospital from June 2020 to June 2023 were selected as the study objects,and were divided into control group(n=59)and observation group(n=60)according to random number table method.The control group was treated with L-asparaginase(L-Asp),and the observation group was treated with PEG-Asp.The clinical efficacy,coagulation indexes,adverse reactions and hospitalization indexes were compared between the two groups.Results There was no significant difference between the observation group and the control group(P＞0.05).There was no significant difference in fibrinogen(FIB),thromboplastin time(APTT)and prothrombin time(PT)between the two groups before treatment(P＞0.05).After treatment,the FIB level of the observation group was lower than that of the control group,and the APTT level was higher than that of the control group,the difference was statistically significant(P＜0.05),and the PT level of the observation group was not statistically significant(P＞0.05).There was no significant difference in the incidence of gastrointestinal reaction,urinary amylase increase and vomiting between the observation group and the control group(P＞0.05).The incidence of liver function impairment and allergy in the observation group was lower than that in the control group,with statistical significance(P＜0.05).The days of hospitalization in the observation group were shorter than those in the control group,and the Times of medication were less than those in the control group,the difference was statistically significant(P＜0.05).Conclusion For ALL children using PEG-Asp treatment effect is better,but it is easy to cause children's coagulation function abnormalities,the use of children should be timely monitoring of coagulation,the drug has a longer half-life,so the frequency of use is low and shorter hospitalisation time,high safety,fewer allergic reactions.