中国免疫学杂志2024，Vol.40Issue(12)：2661-2665,2675,6.DOI:10.3969/j.issn.1000-484X.2024.12.035
冠状病毒调节干扰素应答和炎症反应的研究进展
Research progress on regulation of interferon production and inflammatory response by coronavirus
摘要
Abstract
Coronaviruses are important pathogens that cause respiratory diseases in humans,such as common cold or severe respiratory symptoms.After coronavirus infects host cells,innate immune system recognizes invading virus through sensing its patho-gen-associated molecular patterns with various pattern recognition receptors,and antiviral immune response is activated.Increased production of IFN and pro-inflammatory will inhibit proliferation of coronavirus.In addition,coronavirus has ability to escape innate immune response,which is conducive to proliferation of virus.In this review,we describe relevant studies on regulation of IFN response and inflammatory response of coronaviruses,to provide new ideas for prevention and treatment of coronavirus infection.关键词
冠状病毒/天然免疫/干扰素/炎症反应Key words
Coronavirus/Innate immune/Interferon/Inflammation分类
医药卫生引用本文复制引用
谢莎,郑关民,孙彦刚..冠状病毒调节干扰素应答和炎症反应的研究进展[J].中国免疫学杂志,2024,40(12):2661-2665,2675,6.基金项目
国家自然科学基金(32002294,32102687) （32002294,32102687）
河南省科技攻关项目(212102311040) （212102311040）
河南省青年科学基金(222300420216). （222300420216）
