中国实用内科杂志2024，Vol.44Issue(10)：798-804,7.DOI:10.19538/j.nk2024100102
脑胶质类淋巴系统功能异常与慢性睡眠障碍
Relationship between dysfunction of the glymphatic system and long-term insomnia
摘要
Abstract
This study reviews the structure and function of the glymphatic system and its role in sleep and other neurological diseases.The glymphatic system,composed of astrocytes and perivascular spaces,is responsible for the exchange of interstitial fluid and cerebrospinal fluid,the clearance of metabolic waste from the brain,and the regulation of intracranial pressure.Sleep has a significant impact on the activity of the glymphatic system,with the highest clearance efficiency occurring during deep sleep.Research indicates that the glymphatic system plays a crucial role in waste clearance and regulation in neurological diseases such as Alzheimer's disease,Parkinson's disease,stroke,migraine,and epilepsy.Sleep significantly influences this system's clearance function,and sleep deprivation or disruption can lead to the accumulation of harmful proteins in the brain,exacerbating the development of neurological diseases.Studying the role of the glymphatic system in these diseases can help in understanding their pathogenesis and developing new therapeutic approaches.关键词
脑胶质类淋巴系统/睡眠障碍/功能异常Key words
glymphatic system/sleep disorder/dysfunction分类
医药卫生引用本文复制引用
黄肖珊,张红梅,鲍磊,王钰乔,吴云成,张沈阳..脑胶质类淋巴系统功能异常与慢性睡眠障碍[J].中国实用内科杂志,2024,44(10):798-804,7.基金项目
科技创新2030-"脑科学与类脑研究"重大项目(2021ZD0201900,2021ZD0201905) （2021ZD0201900,2021ZD0201905）
国家自然科学基金(82171243) （82171243）
江苏省卫健委医学科研项目(Z2023089) （Z2023089）
徐州市科技局重点研发计划面上项目(KC23277) （KC23277）
