局解手术学杂志2024，Vol.33Issue(12)：1027-1033,7.DOI:10.11659/jjssx.01E024122
基于脂质组学探究游泳运动对NAFLD小鼠脂质代谢的改善作用
Effect of swimming exercise on lipid metabolism in NAFLD mice based on lipidomics
摘要
Abstract
Objective To investigate the regulatory effect of swimming exercise(SE)on lipid metabolism in nonalcoholic fatty liver disease(NAFLD)mice.Methods A total of 27 C57BL/6J mice were divided into the control group(normal diet),high fat diet(HFD)group and HFD+SE group,with 9 mice in each group.Twelve weeks later,liver tissues were collected for untargeted lipidomics detection by LC-MS.Dimensional statistical analysis of lipidomics profiles was carried out by constructing OPLS-DA model,and combined with the t-test,the lipids with OPLS-DA VIP>1,P<0.05 were screened out from all samples as significantly different lipids.Results There were 81 different lipids between HFD group and the control group;and there were 27 different lipids between HFD+SE group and HFD group.The different lipids mainly belong to glycerides,glycerophospholipids and sphingomyelins.Conclusion Lipid metabolism profile of NAFLD mice has been changed,and swimming exercise can improve lipid metabolism of NAFLD mice.关键词
NAFLD/游泳运动/脂质组学/脂质代谢Key words
NAFLD/swimming exercise/lipidomics/lipid metabolism分类
医药卫生引用本文复制引用
罗燕,邓平,陈梦妍,谢佳,田丽,皮会丰..基于脂质组学探究游泳运动对NAFLD小鼠脂质代谢的改善作用[J].局解手术学杂志,2024,33(12):1027-1033,7.基金项目
国家博士创新人才支持计划(BX201700107) （BX201700107）
