High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial TherapyOA
The current single-atom catalysts(SACs)for medicine still suffer from the limited active site density.Here,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with iron.The constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial effects.Attractively,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading SACs.Consequently,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/C.In addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)depletion.Both in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound healing.This work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.
Si Chen;Fang Huang;Lijie Mao;Zhimin Zhang;Han Lin;Qixin Yan;Xiangyu Lu;Jianlin Shi
Department of Cardiology,Shanghai Tenth People’s Hospital,School of Medicine,Tongji University,Shanghai 200092,People’s Republic of China Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,People’s Republic of ChinaDepartment of Cardiology,Shanghai Tenth People’s Hospital,School of Medicine,Tongji University,Shanghai 200092,People’s Republic of ChinaDepartment of Cardiology,Shanghai Tenth People’s Hospital,School of Medicine,Tongji University,Shanghai 200092,People’s Republic of ChinaShanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,People’s Republic of ChinaShanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,People’s Republic of ChinaDepartment of Cardiology,Shanghai Tenth People’s Hospital,School of Medicine,Tongji University,Shanghai 200092,People’s Republic of ChinaDepartment of Cardiology,Shanghai Tenth People’s Hospital,School of Medicine,Tongji University,Shanghai 200092,People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine,School of Medicine,Tongji University,Shanghai 200092,People’s Republic of ChinaShanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,People’s Republic of China
药学
Nanocatalytic medicineSingle-atom catalystsReactive oxygen species(ROS)High metal loadingOxidase catalysis
《Nano-Micro Letters》 2025 (2)
P.187-203,17
supported by the National Key Research and Development Program of China(Grant No.2022YFB3804500)the National Natural Science Foundation of China(Grant No.52202352,22335006)the Shanghai Municipal Health Commission(Grant No.20224Y0010)the CAMS Innovation Fund for Medical Sciences(Grant No.2021-I2M-5-012)the Basic Research Program of Shanghai Municipal Government(Grant No.21JC1406000)the Fundamental Research Funds for the Central Universities(Grant No.22120230237,2023-3-YB-11,22120220618)the Basic Research Program of Shanghai Municipal Government(23DX1900200).
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