北京生物医学工程2024，Vol.43Issue(6)：584-591,8.DOI:10.3969/j.issn.1002-3208.2024.06.005
静息与充血状态下主动脉血流动力学指标定量关系的研究
The quantitative relationship between resting and hyperemic aortic hemodynamic parameters
摘要
Abstract
Objective To study the quantitative relationship between aortic hemodynamic parameters in resting and hyperemic states can provide theoretical support for the simulation of hyperemia in non-invasive numerical calculation of fractional flow reserve(FFR).Methods 109 patients with coronary heart disease were enrolled in the study.After FFR catheterization,aortic pressure waveforms were extracted for five cycles under resting state and hyperemia state,and four aortic hemodynamic parameters including mean arterial pressure(MAP),systolic blood pressure(SBP),diastolic blood pressure(DBP)and(heart rate)HR were recorded.Patients were randomly divided into a test group(89 patients)and a validation group(20 patients),and the significance of the differences in MAP,SBP,DBP and HR mean values between resting state and hyperemia state in the test group was tested by analysis of variance.The relationship between the four physiological indexes in the state of resting and hyperemia was expressed as the ratios of hyperemia indexes to resting indexes.The validation group used mean square error analysis to verify the results of the test group.Finally,the FFR value was calculated by simulation to verify the reliability of the statistical results.Results Under the condition of hyperemia,MAP,SBP,DBP decreased by(18.79±10.51)mmHg,(25.30±14.84)mmHg,(13.69±7.76)mmHg respectively,and HR increased by(9.82±10.95)times/min in the test group.The ratios of MAP,SBP,DBP and HR at hyperemia and rest were 0.82,0.82,0.82 and 1.1,respectively.The mean square error of MAP,SBP,DBP and HR in the validation group were 0.08,0.05,0.09 and 0.03(all within 10%).The accuracy of FFR calculated using the statistical results of this study to simulate the hyperemic state was 86.7%.Conclusions The results can provide theoretical support for the modeling in non-invasive numerical calculation of FFR.关键词
主动脉血流动力学指标/静息状态/充血状态/血流储备分数/无创数值计算Key words
aortic hemodynamic parameter/resting state/hyperemia/fractional flow reserve/noninvasive numerical calculation分类
医药卫生引用本文复制引用
马俊玲,李娜,吴若婷,李鲍,刘健,刘有军..静息与充血状态下主动脉血流动力学指标定量关系的研究[J].北京生物医学工程,2024,43(6):584-591,8.基金项目
国家自然科学基金(11832003、32271361、12202022、12102014)资助 （11832003、32271361、12202022、12102014）
