赣南医科大学学报2024，Vol.44Issue(11)：1105-1115,11.DOI:10.3969/j.issn.1001-5779.2024.11.003
构建α-酰氧基酮类化合物的研究进展
Advances in the synthesis of α-acyloxy ketones
摘要
Abstract
α-Acyloxy ketone is one of the structural units in pharmaceutical molecules.Its derivatives are widely found in drugs and natural products with essential application value.Meanwhile,α-acyloxy ketone compounds,as a class of key reaction intermediates in the field of synthesis,can be converted into many types of functional groups.The direct α-oxoacylation reaction of ketones is a traditional method to construct α-acyloxy ketones,but it usually uses heavy metals and is not environmentally friendly.The synthesis of α-acyloxy ketones has made positive progress with the gradual development of technologies such as transition-metal catalysis,metal-free synthesis,as well as photo-or electro-assisted synthesis.Given the importance of α-acyloxy ketones,this paper analyzes and summarizes the reactions used for synthesizing α-acyloxy ketones in the last decade,hoping to promote further development in this research field.关键词
α-酰氧基酮/过渡金属催化/无金属合成/光辅助合成/电辅助合成Key words
α-Acyloxy ketones/Transition-metal catalysis/Metal-free synthesis/Photo-assisted synthesis/Electro-assisted synthesis分类
医药卫生引用本文复制引用
黄艳,段海鹏,刘沛沛,付天,雷健,李珊,王姿秀..构建α-酰氧基酮类化合物的研究进展[J].赣南医科大学学报,2024,44(11):1105-1115,11.基金项目
国家自然科学基金项目(22168001) （22168001）
江西省大学生创新创业训练计划项目(S202310413007) （S202310413007）
赣南医学院本科生科技创新项目(ZR2214) （ZR2214）
