赣南医科大学学报2024，Vol.44Issue(11)：1116-1120,5.DOI:10.3969/j.issn.1001-5779.2024.11.004
一锅法合成吡唑并[3,4-b]喹啉酮类化合物
One-pot synthesis of pyrazolo[3,4-b]quinolinone compounds
摘要
Abstract
Objective:To explore green and efficient synthesis methods for pyrazolo[3,4-b]quinolinone compounds(PQO).Methods:PQO were obtained by arylglyoxals,1,3-cyclohexanediones,and 5-amino-3-methyl-1-phenylpyrazole as raw materials via a one-pot three-component reaction.Results:The optimal synthetic process for obtaining PQO was EtOH/H2O(V=1/1)as the solvent,the reaction temperature 50℃,and the reaction time 1.5 hours.The target compounds were confirmed by 1H NMR,13C NMR,and HR-MS.Conclusion:The reaction is characterized by simple operation,high yield,and high atom economy,with potential applications in the design and synthesis of new drugs,combinatorial chemistry,and the synthesis of natural products.关键词
吡唑并[3,4-b]喹啉酮/有机合成/一锅法Key words
Pyrazolo[3,4-b]quinolinone/Organic synthesis/One-pot分类
医药卫生引用本文复制引用
刘昭文,洪朝国,彭凉谦,陶佳怡,王榆榕,周鹏辉,曹一帆,杨凯..一锅法合成吡唑并[3,4-b]喹啉酮类化合物[J].赣南医科大学学报,2024,44(11):1116-1120,5.基金项目
江西省自然科学基金面上项目(20224BAB203010) （20224BAB203010）
江西省高等学校大学生创新创业训练计划项目(S202410413034) （S202410413034）
